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Titolo:
ORIGIN OF CIRCULATING GROUP-II PHOSPHOLIPASE-A2 IN HEPATOCYTES IN A PATIENT WITH EPITHELOID HEMANGIOENDOTHELIOMA OF THE LIVER
Autore:
NEVALAINEN TJ; KALLAJOKI M; PESONEN E; ANDERSSON S; KARKKAINEN P; HOCKERSTEDT K;
Indirizzi:
UNIV TURKU,DEPT PATHOL,KIINAMYLLYNKATU 10 SF-20520 TURKU FINLAND HELSINKI UNIV,DEPT OBSTET & GYNECOL HELSINKI FINLAND HELSINKI UNIV,DEPT PATHOL HELSINKI FINLAND HELSINKI UNIV,DEPT SURG HELSINKI FINLAND
Titolo Testata:
Laboratory investigation
fascicolo: 3, volume: 74, anno: 1996,
pagine: 585 - 591
SICI:
0023-6837(1996)74:3<585:OOCGPI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; SERUM PHOSPHOLIPASE-A2; PANCREATIC PHOSPHOLIPASE-A2; RHEUMATOID-ARTHRITIS; GENE-EXPRESSION; SYNOVIAL-FLUID; INFLAMMATION; DISEASE; PURIFICATION; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Nevalainen et al., "ORIGIN OF CIRCULATING GROUP-II PHOSPHOLIPASE-A2 IN HEPATOCYTES IN A PATIENT WITH EPITHELOID HEMANGIOENDOTHELIOMA OF THE LIVER", Laboratory investigation, 74(3), 1996, pp. 585-591

Abstract

The concentration of group II phospholipase A2 was measured in blood plasma samples before and after liver transplantation in a 27-year-oldwoman who suffered from a massive epitheloid hemangioendothelioma of the liver. The pretransplantation concentration of group II phospholipase A2 was 830 mu g/L, which is markedly above the upper limit of the reference interval (10.8 mu g/L). After the transplantation, there wasa dramatic decrease in the group II phospholipase A2 level (33 mu g/Lon the first posttransplantation day). In situ hybridization of mRNA and immunohistochemistry revealed synthesis of group II phospholipase A2 in hepatocytes in non-neoplastic areas of the liver. Tumor cells did not contain group II phospholipase A2. The results indicate that group II phospholipase A2 circulating in blood plasma originates in hepatocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:43:27