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Titolo:
THE EFFECTS OF GLIBENCLAMIDE, A BLOCKER OF K-SENSITIVE POTASSIUM CHANNELS, ON DIAPHRAGMATIC FATIGUE DURING ENDOTOXEMIA IN PIGS( ATP)
Autore:
AGUGGINI G; DIMORI M; VANELLI G; ALBERTINI M;
Indirizzi:
UNIV MILAN,INST VET PHYSIOL & BIOCHEM,VIA CELORIA 10 I-20133 MILAN ITALY
Titolo Testata:
Veterinary research communications
fascicolo: 2, volume: 20, anno: 1996,
pagine: 183 - 190
SICI:
0165-7380(1996)20:2<183:TEOGAB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTILE FAILURE; RESPIRATORY MUSCLE; BLOOD-FLOW; HEART; MECHANISM; MYOCYTES; SHOCK;
Keywords:
DIAPHRAGM; ENDOTOXEMIA; ESCHERICHIA COLI; FATIGUE; GLIBENCLAMIDE; POTASSIUM CHANNEL; SHOCK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G. Aguggini et al., "THE EFFECTS OF GLIBENCLAMIDE, A BLOCKER OF K-SENSITIVE POTASSIUM CHANNELS, ON DIAPHRAGMATIC FATIGUE DURING ENDOTOXEMIA IN PIGS( ATP)", Veterinary research communications, 20(2), 1996, pp. 183-190

Abstract

An in vivo porcine model of endotoxaemia was used to study the effects of glibenclamide, a K(+)ATP-sensitive potassium channel blocker. Escherichia coli lipopolysaccharides (LPS, 70 mu g/kg, i.v., as a bolus) were infused into anaesthetized, mechanically ventilated, indomethacin-treated pigs. After 120 min of endotoxaemia, glibenclamide was administered (10 mg/kg, i.v., over 5 min) to half the pigs. The strength at different frequencies of stimulation (10, 20, 30, 50 Hz, 20 V, 1 s) and the endurance capacity (10 Hz, 20 V, 30 s) of the diaphragm were evaluated after 120 min of endotoxaemia and 5, 10, 20 and 30 min after drug infusion. Glibenclamide transiently increased the blood pressure without changing the decreased cardiac output and at the same time further impaired the diaphragmatic activity. The reduced ability of the diaphragm to generate force in response to different electrical stimulations was shown by a significant reduction in strength. The endurance index decreased 5 min after glibenclamide infusion, returning to the pre-glibenclamide values by 150 min. These results indicate that glibenclamide modifies the activity of vascular smooth muscle and of the diaphragm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 14:23:41