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Titolo:
EVIDENCE FOR DISTINCT SIGNALING MECHANISMS IN 2 MAMMALIAN OLFACTORY SENSE-ORGANS
Autore:
BERGHARD A; BUCK LB; LIMAN ER;
Indirizzi:
HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT NEUROBIOL BOSTON MA 02115
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 6, volume: 93, anno: 1996,
pagine: 2365 - 2369
SICI:
0027-8424(1996)93:6<2365:EFDSMI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLYL CYCLASE; VOMERONASAL SYSTEM; ODORANT RECEPTORS; MARKER PROTEIN; EXPRESSION; RAT; ORGANIZATION; NEURONS; FAMILY; GENE;
Keywords:
VOMERONASAL ORGAN; PHEROMONE; SENSORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A. Berghard et al., "EVIDENCE FOR DISTINCT SIGNALING MECHANISMS IN 2 MAMMALIAN OLFACTORY SENSE-ORGANS", Proceedings of the National Academy of Sciences of the United Statesof America, 93(6), 1996, pp. 2365-2369

Abstract

In mammals, olfactory stimuli are detected by sensory neurons at two distinct sites: the olfactory epithelium (OE) of the nasal cavity and the neuroepithelium of the vomeronasal organ (VNO). While the OE can detect volatile chemicals released from numerous sources, the VNO appears to be specialized to detect pheromones that are emitted by other animals and that convey information of behavioral or physiological importance. The mechanisms underlying sensory transduction in the OE have been well studied and a number of components of the transduction cascade have been cloned. Here, we investigated sensory transduction in the VNO by asking whether VNO neurons express molecules that have been implicated in sensory transduction in the OE. Using in situ hybridizationand Northern blot analyses, we found that most of the olfactory transduction components examined, including the guanine nucleotide binding protein cy subunit (G(alpha oIf)), adenylyl cyclase type III, and an olfactory cyclic nucleotide-gated (CNG) channel subunit (oCNC1), are not expressed by VNO sensory neurons. In contrast, VNO neurons do express a second olfactory CNG channel subunit (oCNC2). These results indicate that VNO sensory transduction is distinct from that in the OE but raise the possibility that, like OE sensory transduction, sensory transduction in the VNO might involve cyclic nucleotide-gated ion channels.

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Documento generato il 21/09/20 alle ore 19:05:25