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Titolo:
MURINE BONE-MARROW TRANSPLANTATION AS A NOVEL-APPROACH TO STUDYING THE ROLE OF MACROPHAGES IN LIPOPROTEIN METABOLISM AND ATHEROGENESIS
Autore:
FAZIO S; LINTON MF;
Indirizzi:
VANDERBILT UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL NASHVILLE TN 37232
Titolo Testata:
Trends in cardiovascular medicine
fascicolo: 2, volume: 6, anno: 1996,
pagine: 58 - 65
SICI:
1050-1738(1996)6:2<58:MBTAAN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-E DEFICIENCY; E MESSENGER-RNA; HERITABLE HYPERLIPIDEMIC RABBITS; APOPROTEIN-E; MOUSE MACROPHAGES; TRANSGENIC MICE; III HYPERLIPOPROTEINEMIA; ATHEROSCLEROTIC LESIONS; CHOLESTEROL DEPOSITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
S. Fazio e M.F. Linton, "MURINE BONE-MARROW TRANSPLANTATION AS A NOVEL-APPROACH TO STUDYING THE ROLE OF MACROPHAGES IN LIPOPROTEIN METABOLISM AND ATHEROGENESIS", Trends in cardiovascular medicine, 6(2), 1996, pp. 58-65

Abstract

In recent years, the development of transgenic and gene targeting technologies have made the mouse a powerful model to dissect the contribution of various genes to lipoprotein metabolism and atherosclerosis susceptibility. Here, murine bone marrow transplantation (BMT) is presented as a method to investigate the role of the macrophage in lipoprotein metabolism and atherosclerosis. This approach has been successfullyimplemented in apolipoprotein (apo) E-deficient mice, which develop severe hyperlipidemia and extensive aortic and coronary atherosclerosis. BMT was performed as a way to deliver macrophages with the normal complement of the apoE gene to the apoE-deficient mice. BMT resulted in the appearance of apoE in plasma, in a sustained drop in cholesterol levels, and in the normalization of the lipoprotein profile. In addition, BMT protected the apoE-deficient mice from diet-induced hypercholesterolemia and atherosclerosis. These data demonstrate that extrahepatic apoE secreted into the plasma compartment is functionally active andpromotes lipoprotein clearance, and establish BMT as a novel approachto dissecting the role of macrophages in atherosclerosis and lipid metabolism In addition, these findings show that the liver is not the obligatory target organ in gene therapy of dyslipidemia, and suggest theuse of the macrophage as a vehicle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:48:01