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Titolo:
DOPAMINE AND 5-HT RECEPTOR SENSITIVITY DOES NOT CORRELATE WITH NEOSTRIATAL DOPAMINE OR 5-HT CONTENT
Autore:
KOSTRZEWA RM; BRUS R; PERRY KW; FULLER RW;
Indirizzi:
E TENNESSEE STATE UNIV,QUILLEN DISHNER COLL MED,DEPT PHARMACOL JOHNSON CITY TN 37614 L WARYNSKI SILESIAN MED ACAD,DEPT PHARMACOL PL-41808 ZABRZE POLAND ELI LILLY & CO,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Acta Neurobiologiae Experimentalis
fascicolo: 1, volume: 56, anno: 1996,
pagine: 21 - 28
SICI:
0065-1400(1996)56:1<21:DA5RSD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL 6-OHDA-LESIONED RATS; BEHAVIORAL-RESPONSES; ORAL ACTIVITY; 6-HYDROXYDOPAMINE; AGONIST; SUPERSENSITIZATION; D1-DOPAMINE; DYSKINESIA; INDUCTION;
Keywords:
DOPAMINE; DOPAMINE RECEPTORS; NEOSTRIATUM; ORAL DYSKINESIAS; RECEPTOR SUPERSENSITIVITY; SEROTONIN; 5-HT RECEPTORS; 6-HYDROXYDOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Kostrzewa et al., "DOPAMINE AND 5-HT RECEPTOR SENSITIVITY DOES NOT CORRELATE WITH NEOSTRIATAL DOPAMINE OR 5-HT CONTENT", Acta Neurobiologiae Experimentalis, 56(1), 1996, pp. 21-28

Abstract

To explore associations of neostriatal (NST) endogenous levels of dopamine (DA) and serotonin (5-HT) with sensitivity of their receptors, graded doses of 6-hydroxydopamine HBr (0 to 400 mu g, ICV; 6-OHDA; desipramine pretreatment, 20 mg/kg IP) were given to rats' between birth (P 0) and P 42. Numbers of vacuous chewing movements (VCMs) induced by SKF 38393 or m-chlorophenylpiperazine (m-CPP), respective DA D-1 and 5-HT2 agonists, were subsequently determined. Enhanced SKF 38393-induced VCMs occurred when NST DA was reduced 97%-98% by high dose 6-OHDA (100-134 mu g) at P 0 or P 3, but not in rats with 95%-97% loss in DA produced by 6-OHDA at P7 (134 mu g) or P3 (67 mu g). Enhanced m-CPP-induced VCMs occurred even when NST 5-HT content was not elevated after 6-OHDA (134 mu g at P 10). Accordingly, D-1 and 5-HT receptor sensitivity is not correlated with respective NST DA and 5-HT contents. The stage of ontogeny at the time of DA denervation may be the governing influence on receptor sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:26:50