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Titolo:
IDENTIFICATION OF HYALURONIC-ACID AND CHONDROITIN SULFATES IN HUMAN FOLLICULAR-FLUID AND THEIR EFFECTS ON HUMAN SPERM MOTILITY AND THE OUTCOME OF IN-VITRO FERTILIZATION
Autore:
HAMAMAH S; WITTEMER C; BARTHELEMY C; RICHET C; ZERIMECH F; ROYERE D; DEGAND P;
Indirizzi:
CHU BRETONNEAU,DEPT GYNECOL OBSTET REPROD & MED FOETALE,UNITE BIOL REPROD F-37044 TOURS FRANCE CTR MEDICOCHIRURG & OBSTET SECUR SOCIALE F-67303 SCHILTIGHEIM FRANCE CHRU HURIEZ,BIOCHIM LAB F-59045 LILLE FRANCE CHRU HURIEZ,INSERM 377 F-59045 LILLE FRANCE
Titolo Testata:
Reproduction, nutrition, development
fascicolo: 1, volume: 36, anno: 1996,
pagine: 43 - 52
SICI:
0926-5287(1996)36:1<43:IOHACS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CUMULUS-OOPHORUS; ACROSOME REACTION; HUMAN-SPERMATOZOA; INVITRO FERTILIZATION; BOVINE SPERMATOZOA; GLYCOSAMINOGLYCANS; PROTEOGLYCAN; SURFACE;
Keywords:
GLYCOSAMINOGLYCAN; HUMAN FOLLICULAR FLUID; SPERMATOZOA; MOTILITY; IVF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S. Hamamah et al., "IDENTIFICATION OF HYALURONIC-ACID AND CHONDROITIN SULFATES IN HUMAN FOLLICULAR-FLUID AND THEIR EFFECTS ON HUMAN SPERM MOTILITY AND THE OUTCOME OF IN-VITRO FERTILIZATION", Reproduction, nutrition, development, 36(1), 1996, pp. 43-52

Abstract

This study measured glycosaminoglycans (GAGs) in human follicular fluid (hFF) obtained from patients undergoing hormonal stimulation with combined GnRH agonist followed by gonadotropin hormone (hMG or FSH) forin vitro fertilization (IVF). The GAGs were partially characterized through the use of various mucopolysaccharidases and then their effectstested on human sperm motility. In hFF, the GAG and protein concentrations were 4.4 +/- 1.3 mg/L and 32.6 +/- 3.2 g/L respectively. Chondroitins (CS) and hyaluronic acid (HA) significantly stimulate sperm motion in comparison to the control. The oocytes inseminated with GAGs-pretreated spermatozoa showed a significantly higher rate of cleavage andpregnancy or delivered number. The present results suggest that hFF is a rich source of sulfated glycosaminoglycan (CS), and non-sulfated glycosaminoglycan (HA). The stimulatory effects of hFF on human sperm motility may well depend on CS and HA. GAGs pretreated sperm may enhance the fertilizing ability of spermatozoa and thus the IVF outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:25:31