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Titolo:
MAPPING OF THE LINEAR ANTIGENIC DETERMINANTS FROM THE LEISHMANIA-INFANTUM HISTONE H2A RECOGNIZED BY SERA FROM DOGS WITH LEISHMANIASIS
Autore:
SOTO M; REQUENA JM; QUIJADA L; GARCIA M; GUZMAN F; PATARROYO ME; ALONSO C;
Indirizzi:
UNIV AUTONOMA MADRID,CTR BIOL MOLEC SEVERO OCHOA E-28049 MADRID SPAIN UNIV AUTONOMA MADRID,CTR BIOL MOLEC SEVERO OCHOA E-28049 MADRID SPAIN HOSP SAN JUAN DIOS,INST IMMUNOL SANTA FE BOGOTA COLOMBIA UNIV EXTREMADURA,FAC VET,DEPT MED & SANIDAD ANIM E-10071 CACERES SPAIN
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 48, anno: 1995,
pagine: 209 - 214
SICI:
0165-2478(1995)48:3<209:MOTLAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR CHARACTERIZATION; VISCERAL LEISHMANIASIS; SURFACE GLYCOPROTEIN; ANTIBODY; EXPRESSION; PROTEINS; GENES;
Keywords:
ANTIHISTONE ANTIBODY; CANINE LEISHMANIASIS; SYNTHETIC PEPTIDE; B-CELL EPITOPE; HISTONE H2A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Soto et al., "MAPPING OF THE LINEAR ANTIGENIC DETERMINANTS FROM THE LEISHMANIA-INFANTUM HISTONE H2A RECOGNIZED BY SERA FROM DOGS WITH LEISHMANIASIS", Immunology letters, 48(3), 1995, pp. 209-214

Abstract

Antibodies reacting against the H2A histone protein were frequently observed in the sera from dogs naturally infected with the protozoan parasite Leishmania infantum. Using synthetic peptides covering the complete sequence of the protein we have identified the amino terminal region, comprising from amino acids 1 to 20, and the carboxyl terminal region, comprising from amino acids 106 to 132, as conforming the antigenic determinants of the protein. Those regions, exposed in the nucleosome surface, are highly divergent in sequence relative to the mammalian H2A histones. The anti-H2A histone antibodies present in the sera ofthese dogs specifically recognize the L, infantum H2A histone and they do not react with mammalian histones. The present data indicate that, in spite of the evolutionary conservation of the H2A histone proteinamong eukaryotic organisms, the humoral response against this proteinduring natural infection is specifically triggered by the parasite protein antigenic determinants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:43:01