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Titolo:
TRANSACTIVATION OF A CELLULAR PROMOTER BY THE NS1 PROTEIN OF PARVOVIRUS MINUTE VIRUS OF MICE THROUGH A PUTATIVE HORMONE-RESPONSIVE ELEMENT
Autore:
VANACKER JM; CORBAU R; ADELMANT G; PERROS M; LAUDET V; ROMMELAERE J;
Indirizzi:
DEUTSCH KREBSFORSCHUNGSZENTRUM,TUMOR VIROL UNIT,ABT 0610,NEUENHEIMER FELD 242,P 101949 D-69009 HEIDELBERG GERMANY INST PASTEUR,CNRS,URA 1160,INSERM,U375 LILLE FRANCE
Titolo Testata:
Journal of virology
fascicolo: 4, volume: 70, anno: 1996,
pagine: 2369 - 2377
SICI:
0022-538X(1996)70:4<2369:TOACPB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROIDOGENIC FACTOR-I; TRANSFORMED RAT-CELLS; H-1 P38 PROMOTER; THYROID-HORMONE; NUCLEAR RECEPTOR; NONSTRUCTURAL PROTEIN; GENE; EXPRESSION; DNA; SENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Vanacker et al., "TRANSACTIVATION OF A CELLULAR PROMOTER BY THE NS1 PROTEIN OF PARVOVIRUS MINUTE VIRUS OF MICE THROUGH A PUTATIVE HORMONE-RESPONSIVE ELEMENT", Journal of virology, 70(4), 1996, pp. 2369-2377

Abstract

The promoter of the thyroid hormone receptor cr gene (c-ErbA-1) is activated by the nonstructural protein 1 (NS1) of parvovirus minute virus of mice (prototype strain [MVMp]) in ras-transformed FREJ4 cells that are permissive for lytic MVMp replication. This stimulation may be related to the sensitivity of host cells to MVMp, as it does not take place in parental FR3T3 cells, which are resistant to the parvovirus killing effect. The analysis of a series of deletion and point mutants of the c-erbA-1 promoter led to the identification of an upstream region that is necessary for NS1-driven transactivation. This sequence harbors a putative hormone-responsive element and is sufficient to render a minimal promoter NS1 inducible in FREJ4 but not in FR3T3 cells, and it is involved in distinct interactions with proteins from the respective cell lines. The NS1-responsive element of the c-erbA-1 promoter bears no homology with sequences that were previously reported to be necessary for NS1 DNA binding and transactivation. Altogether, our data point to a novel, cell-specific mechanism of promoter activation by NS1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:01:06