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Titolo:
INJECTIONS OF CORTICOTROPIN-RELEASING FACTOR INTO THE PERIAQUEDUCTAL GRAY ENHANCE PAVLOVIAN FEAR CONDITIONING
Autore:
TERSHNER SA; HELMSTETTER FJ;
Indirizzi:
UNIV WISCONSIN,DEPT PSYCHOL,POB 413 MILWAUKEE WI 53201 UNIV WISCONSIN,DEPT PSYCHOL MILWAUKEE WI 53201
Titolo Testata:
Psychobiology
fascicolo: 1, volume: 24, anno: 1996,
pagine: 49 - 56
SICI:
0889-6313(1996)24:1<49:IOCFIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; FACTOR RECEPTORS; RATS; AMYGDALA; BEHAVIOR; NUCLEUS; FACILITATION; HIPPOCAMPUS; NALTREXONE; ANTAGONISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Tershner e F.J. Helmstetter, "INJECTIONS OF CORTICOTROPIN-RELEASING FACTOR INTO THE PERIAQUEDUCTAL GRAY ENHANCE PAVLOVIAN FEAR CONDITIONING", Psychobiology, 24(1), 1996, pp. 49-56

Abstract

Two experiments were conducted to determine if central administrationof corticotropin-releasing factor (CRF) could influence the acquisition of a conditional fear response. In the first experiment, rats received either CRF (1.0 mu g) or saline into the lateral ventricle prior to Pavlovian fear conditioning. Twenty-four hours later, freezing to the shock-associated context and the shock-associated discrete stimulus was measured. Subjects that received CRF prior to conditioning engagedin more freezing behavior to both types of stimuli than did the saline controls. In the second experiment, rats received either CRF (0.4 mug) or saline into the ventral area of the midbrain periaqueductal gray (FAG) prior to fear conditioning. Direct application of CRF into theFAG also produced an enhancement in fear conditioning to both discrete and contextual stimuli. These results suggest that CRF is capable ofmodulating the acquisition of fear responses through a neural system that includes the PAG.

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Documento generato il 19/01/20 alle ore 09:07:51