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Titolo:
THE RELATIONSHIP BETWEEN VASCULARITY AND CELL-PROLIFERATION IN HUMAN NORMAL AND PATHOLOGICAL LESIONS OF THE ORAL CHEEK EPITHELIUM
Autore:
TIPOE GL; JIN Y; WHITE FH;
Indirizzi:
UNIV HONG KONG,DEPT ANAT HONG KONG HONG KONG FOURTH MIL MED UNIV,QIN DU STOMATOL HOSP,DEPT ORAL PATHOL XIAN 710032PEOPLES R CHINA
Titolo Testata:
European journal of cancer. Part B, Oral oncology
fascicolo: 1, volume: 32B, anno: 1996,
pagine: 24 - 31
SICI:
0964-1955(1996)32B:1<24:TRBVAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR ANTIGEN PCNA; MONOCLONAL-ANTIBODIES; PROGNOSTIC INDICATOR; TUMOR ANGIOGENESIS; PARAFFIN SECTIONS; EXPRESSION; CARCINOMA; NEOPLASMS; METASTASIS; DYSPLASIA;
Keywords:
PCNA; ORAL CANCER; HUMAN; BLOOD VESSELS; ANGIOGENESIS; CELL PROLIFERATION; MORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
G.L. Tipoe et al., "THE RELATIONSHIP BETWEEN VASCULARITY AND CELL-PROLIFERATION IN HUMAN NORMAL AND PATHOLOGICAL LESIONS OF THE ORAL CHEEK EPITHELIUM", European journal of cancer. Part B, Oral oncology, 32B(1), 1996, pp. 24-31

Abstract

The present study investigates relationships between neovascularisation and PCNA cell proliferation markers in different pathological lesions of the oral cheek mucosa. All specimens were fixed in 10% formalin and routinely processed for histology. Six normal (N) samples were taken from resection margins of benign lesions, The pathological lesions consisted of chronic inflammation (n=10), lichen planus (n=7), fibroushyperplasia (n=11), dysplasia (n=5), squamous cell carcinoma (n=22) and epithelium adjacent to carcinoma (n=6). Adjacent 5 mu m sections were stained with monoclonal antibodies against vimentin (clone no. V9) for identification of stromal blood vessels and against proliferating nuclear antigen (PCNA/PC10) using ABC immunoperoxidase techniques. Point counting was used to obtain the primary morphometric data using a Zeiss VIDAS image analyser. No attempt was made to classify the different types of blood vessels. The morphometric blood vessel parameters estimated were volume density, number per unit area, length per unit volume and mean transverse sectional area. PCNA indices were determined by estimating the percentage frequency of PCNA positive nuclei in basaland spinous strata. Generally, there were significant increases in all PCNA indices and blood vessel parameters between the N group and thedifferent pathological lesions. A highly positive correlation was detected between all PCNA indices and blood vessel parameters. These datasuggest that increased vascularity and angiogenesis occur in support of actively proliferating and transforming oral epithelial cells in order to permit growth. PCNA indices and blood vessel parameters may have a potential application as diagnostic and prognostic indicators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:48:06