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Titolo:
E-CADHERIN IS INVOLVED IN THE INTRAHEPATIC METASTASIS OF HEPATOCELLULAR-CARCINOMA
Autore:
OSADA T; SAKAMOTO M; INO Y; IWAMATSU A; MATSUNO Y; MUTO T; HIROHASHI S;
Indirizzi:
NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU,5-1-1 TSUKIJI TOKYO 104 JAPAN NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU TOKYO 104 JAPAN UNIV TOKYO,FAC MED,DEPT SURG 1 TOKYO 113 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL KANAGAWA JAPAN
Titolo Testata:
Hepatology
fascicolo: 6, volume: 24, anno: 1996,
pagine: 1460 - 1467
SICI:
0270-9139(1996)24:6<1460:EIIITI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; DOWN-REGULATION; GASTRIC-CANCER; EXPRESSION; PROTEINS; INVASION; PATTERNS; TUMORS; DEDIFFERENTIATION; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
T. Osada et al., "E-CADHERIN IS INVOLVED IN THE INTRAHEPATIC METASTASIS OF HEPATOCELLULAR-CARCINOMA", Hepatology, 24(6), 1996, pp. 1460-1467

Abstract

In human hepatocellular carcinoma (HCC), the liver is the major target organ of metastasis, which is known as intrahepatic metastasis. To analyze the mechanism of this metastasis, we established two sublines from the human HCG cell line Li7. Subline Li7HM produced multiple Livermetastasis, whereas subline Li7NM never did so after intrasplenic injection into nude mice. Two-dimensional gel electrophoresis and immunoblot analysis showed that only Li7NM expressed vimentin and lacked E-cadherin expression, indicating that this clone had undergone epithelial-mesenchymal transition. We then transfected mouse E-cadherin complementary DNA into Li7NM cells and found that the transfectant cells (EM16.21B.3) formed liver metastasis (8/16 mice) after intrasplenic injection and liver tumors (11/13 mice) after intrahepatic injection, whereasthe control cell line formed no tumors, These results suggest that E-cadherin plays an important role in the process of intrahepatic metastasis of HCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:33:18