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Titolo:
SERUM HYALURONATE REFLECTS HEPATIC FIBROGENESIS IN ALCOHOLIC LIVER-DISEASE AND IS USEFUL AS A MARKER OF FIBROSIS
Autore:
PARES A; DEULOFEU R; GIMENEZ A; CABALLERIA L; BRUGUERA M; CABALLERIA J; BALLESTA AM; RODES J;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,ALCOHOL UNIT,C VILLARROEL 170 E-08036BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,LIVER UNIT BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,BIOCHEM LAB BARCELONA SPAIN
Titolo Testata:
Hepatology
fascicolo: 6, volume: 24, anno: 1996,
pagine: 1399 - 1403
SICI:
0270-9139(1996)24:6<1399:SHRHFI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; III PROCOLLAGEN PEPTIDE; AMINOTERMINAL PROPEPTIDE; PERIVENULAR FIBROSIS; ENDOTHELIAL-CELLS; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Pares et al., "SERUM HYALURONATE REFLECTS HEPATIC FIBROGENESIS IN ALCOHOLIC LIVER-DISEASE AND IS USEFUL AS A MARKER OF FIBROSIS", Hepatology, 24(6), 1996, pp. 1399-1403

Abstract

The high levels of hyaluronic acid (HA), a glycosaminoglycan of the liver extracellular matrix, which is synthesized and degraded in the liver sinusoidal cells, have been related with a decreased function of the endothelial sinusoidal cells. The relevance of HA in alcoholic liver disease has not been sufficiently evaluated, and therefore the current study was addressed to assess whether serum HA reflects the severity of liver fibrosis and fibrogenesis as well as the potential usefulness of hyaluronic acid as a marker of early fibrosis in alcoholics withliver damage. Serum HA and aminoterminal propeptide of collagen III (PIIIP) levels, a marker of liver fibrogenesis in alcoholics with liverdisease, were assessed in 45 chronic alcoholic patients (31 men and 14 women, age: 44.1 +/- 1.5 years) (normal liver = 7; fatty changes = 8; fibrosis = 7; alcoholic hepatitis = 6; cirrhosis = 6; and cirrhosis plus alcoholic hepatitis = 11). The severity of liver inflammation andfibrosis were scored in liver specimens as: 0, no lesion; 1+ mild; 2moderate; and 3+ severe. Twenty-seven patients (60%) had HA above normal values (1 patient with fatty changes, 3 patients with fibrosis, and all patients with alcoholic hepatitis or cirrhosis). Hyaluronic acidand (PIIIP) levels increased in parallel with the severity of liver damage. Hyaluronic acid levels were higher in those patients with more liver inflammation (0, 128 +/- 38; 1+, 553 +/- 141; 2+, 668 +/- 259; 3, and 1,073 +/- 419 mu g/L; P = .004) and of fibrosis (0, 79 +/- 32; 1+, 156 +/- 70; 2+, 219 +/- 105; and 3+, 695 +/- 114 mu g/L; P < .001). Procollagen III peptide levels were related with fibrosis (0, 17 +/-1; 1+, 25 +/- 6; 2+, 47 +/- 13; 3+, and 55 +/- 9 ng/mL; P = .002) butnot with inflammation (0, 29 +/- 7; 1+, 45 +/- 7; 2+, 54 +/- 9; 3+, and 66 +/- 30 ng/mL, P: not significant). Moreover, a direct linear correlation was observed between HA and PIIIP (r = .72, P < .001). A receiver operating characteristic (ROC) curve analysis revealed that HA was similar to PIIIP levels in discriminating between alcoholics withoutfibrosis and those with fibrosis (area under the ROC curves) .913 +/-.042 vs. .867 +/- .054; P: n.s). hn conclusion, serum HA reacts the severity of liver inflammation, fibrosis, and fibrogenesis in patients with alcoholic liver disease and is useful as a marker of precirrhoticand cirrhotic stages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:41:55