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Titolo:
PRENATAL COCAINE EXPOSURE AFFECTS THE ACOUSTIC STARTLE RESPONSE IN ADULT-RATS
Autore:
HUGHES HE; DONOHUE LM; DOWEDWARDS DL;
Indirizzi:
SUNY HLTH SCI CTR,DEPT PHARMACOL,CEREBRAL METAB LAB,BOX 29,450 CLARKSON AVE BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT PHARMACOL,CEREBRAL METAB LAB BROOKLYN NY 11203
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 75, anno: 1996,
pagine: 83 - 90
SICI:
0166-4328(1996)75:1-2<83:PCEATA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE; BEHAVIOR; BRAIN; FETAL; MODULATION; TOXICITY; ANIMALS;
Keywords:
DEVELOPMENT; ACOUSTIC STARTLE REFLEX; COCAINE; AMPHETAMINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H.E. Hughes et al., "PRENATAL COCAINE EXPOSURE AFFECTS THE ACOUSTIC STARTLE RESPONSE IN ADULT-RATS", Behavioural brain research, 75(1-2), 1996, pp. 83-90

Abstract

This study investigated whether prenatal exposure to cocaine alters reflex excitability in adulthood. Pregnant rats received 30 or 60 mg/kg/day cocaine HCl i.g. during gestational days 8-22. Vehicle treated control rats were pair-fed/watered to rats receiving 60 mg/kg cocaine. Anon-treated control group was also maintained. At parturition, litters from all four groups were surrogate fostered and then weaned at 21 days of age. In adulthood, rats were tested in an acoustic startle response (ASR) apparatus for 120 trials using a 116 dB signal on 2 consecutive days. On Day 2: subjects received a single injection of d-amphetamine sulfate s.c. (1.0 mg/kg) just prior to testing. ASR amplitude andlatency were recorded. For average amplitude, significant effects forprenatal treatment were observed. Cocaine-exposed female rats demonstrated decreased ASR amplitude compared to offspring of pair-fed controls during both the initial test Session and following amphetamine administration as well. Overall, amphetamine increased startle. For latency, there were no significant treatment effects or effects of amphetamine administration. However, preplanned comparisons indicated that prenatal cocaine exposure interacted with trial block. Therefore, these data indicate that prenatal cocaine decreased startle amplitude in adults, primarily in females, and that startle-elicited amphetamine responses were dampened as well. The effects on latency indicate that amphetamine does not alter reaction times in prenatal cocaine exposed rats while it does in controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:57:59