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Titolo:
GLUCOSE REGULATION AND COGNITIVE FUNCTIONS - RELATION TO ALZHEIMERS-DISEASE AND DIABETES
Autore:
MESSIER C; GAGNON M;
Indirizzi:
UNIV OTTAWA,SCH PSYCHOL,VANIER ROOM 215 OTTAWA ON K1N 6N5 CANADA ROYAL OTTAWA HOSP,MENTAL HLTH RES INST OTTAWA ON K1Z 7K4 CANADA
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 75, anno: 1996,
pagine: 1 - 11
SICI:
0166-4328(1996)75:1-2<1:GRACF->2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; MEMORY-IMPROVING ACTION; BLOOD-BRAIN-BARRIER; SENILE DEMENTIA; ACETYLCHOLINE SYNTHESIS; CEREBRAL GLUCOSE; ELDERLY HUMANS; ENERGY-METABOLISM; INDUCED DEFICITS; D-AMPHETAMINE;
Keywords:
AGING; GLUCOSE TRANSPORTER; INSULIN; MEMORY; METABOLISM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
126
Recensione:
Indirizzi per estratti:
Citazione:
C. Messier e M. Gagnon, "GLUCOSE REGULATION AND COGNITIVE FUNCTIONS - RELATION TO ALZHEIMERS-DISEASE AND DIABETES", Behavioural brain research, 75(1-2), 1996, pp. 1-11

Abstract

Glucose has been found to improve memory in animals and humans. Animal research has revealed that glucose may improve memory through a facilitation of acetylcholine (ACh) synthesis and release in the brain. This glucose-related memory improvement has prompted research in elderlyhumans. These studies have shown that the memory-improving action of glucose depends on each individuals' blood glucose regulation. Based on these data, researchers have evaluated the effect of glucose on memory in patients with Alzheimer's disease (AD). Results demonstrated that glucose could improve memory in a subset of patients that had abnormalities in their blood glucose regulation. Interestingly, these alterations in blood glucose regulation were believed to depend on the severity of the disease process. Another line of investigation has focused on alterations in brain glucose metabolism. Both animal models and studies with Type II diabetic elderly patients have shown that altered glucose regulation impairs learning and memory processes. It is possiblethat in AD patients, hyperglycemia exerts a deleterious effect by potentiating the neuronal death produced by other pathological processes taking place such as amyloid deposition. Based on these data, it appears important to find the prevalence of altered glucoregulation at various stages of AD. Secondly, it may be of interest to determine prospectively whether altered glucoregulation is linked to a faster progression of the disease. Finally, if such a relationship is observed, the next logical step would be to determine whether AD patients could benefit from treatments aimed at normalizing blood glucose regulation and improving insulin sensitivity.

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Documento generato il 29/11/20 alle ore 00:36:37