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Titolo:
GENE OVEREXPRESSION REVEALS ALTERNATIVE MECHANISMS THAT INDUCE GCN4 MESSENGER-RNA TRANSLATION
Autore:
TAVERNARAKIS N; ALEXANDRAKI D; LIODIS P; TZAMARIAS D; THIREOS G;
Indirizzi:
RUTGERS STATE UNIV,DEPT MOL BIOL & BIOCHEM,CTR ADV BIOTECHNOL & MED,679 HOES LANE,CABM BLDG PISCATAWAY NJ 08855 FDN RES & TECHNOL,INST MOL BIOL & BIOTECHNOL IRAKLION 71110 GREECE UNIV CRETE,DEPT BIOL IRAKLION GREECE
Titolo Testata:
Gene
fascicolo: 2, volume: 179, anno: 1996,
pagine: 271 - 277
SICI:
0378-1119(1996)179:2<271:GORAMT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; MESSENGER-RNA; PROTEIN-KINASE; YEAST; INITIATION; ACTIVATION; MUTATIONS; EXPRESSION; SUBUNITS; MRP;
Keywords:
AMINO-ACID STARVATION; EIF-2; GCNZ; NMEI; PHOSPHORYLATION; TPKZ; TRANSFER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
N. Tavernarakis et al., "GENE OVEREXPRESSION REVEALS ALTERNATIVE MECHANISMS THAT INDUCE GCN4 MESSENGER-RNA TRANSLATION", Gene, 179(2), 1996, pp. 271-277

Abstract

The Saccharomyces cerevisiae GCN4 gene which encodes the transcription activator Gcn4, is under translational regulation. Derepression of GCN4 mRNA translation is mediated by the Gcn2 protein kinase which phosphorylates the a subunit of eIF-2, upon amino-acid starvation. Here, we report that overexpression of certain Saccharomyces cerevisiae genesgenerates intracellular conditions that alleviate the requirement fora functional Gcn2 kinase to induce GCN4 mRNA translation. Our findings, combined with the fact that Gcn2 kinase is dispensable during the initiation phase of the cellular response to amino-acid limitation, provide the grounds to further elucidate the mechanisms underlying the physiology of this homeostatic response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:08:03