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Titolo:
ALDOSTERONE - INTRACELLULAR RECEPTORS IN HUMAN HEART
Autore:
BONVALET JP; ALFAIDY N; FARMAN N; LOMBES M;
Indirizzi:
UNIV PARIS 07,FAC MED XAVIER BICHAT,INSERM U246,IFR CELLULES EPITHELIALES,BP 416 F-75870 PARIS 18 FRANCE
Titolo Testata:
European heart journal
, volume: 16, anno: 1995, supplemento:, N
pagine: 92 - 97
SICI:
0195-668X(1995)16:<92:A-IRIH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
11-BETA-HYDROXYSTEROID DEHYDROGENASE; TARGET-CELLS; MINERALOCORTICOID RECEPTOR; ISOFORM;
Keywords:
CORTICOSTEROID HORMONES; CARDIOMYOCYTES; MINERALOCORTICOID RECEPTORS; 11-BETA HYDROXYSTEROID DEHYDROGENASE; CARDIAC FIBROSIS; HEART FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Bonvalet et al., "ALDOSTERONE - INTRACELLULAR RECEPTORS IN HUMAN HEART", European heart journal, 16, 1995, pp. 92-97

Abstract

It has been suggested that aldosterone exerts direct effects on heartfunctioning, in particular by inducing cardiac fibrosis. We examined human heart tissue for the expression of aldosterone receptors (mineralocorticoid receptors, MRs) and of the MR-protecting enzyme, 11 beta hydroxysteroid dehydrogenase (11 beta HSD). In situ hybridization usingcRNA probes specific for human MRs revealed the presence of mRNA encoding for MRs in cardiomyocytes. Immunohistochemistry with specific antibodies against the MR exhibited the expression of MR protein in cardiomyocytes. In contrast, intramyocardial small blood vessels showed no evidence of immunolabelling. A distinct 11 beta HSD activity, which was nicotinamide-adenine dinucleotide dependent, was also demonstrated in human cardiac tissue. These results illustrate that all the components required for a specific aldosterone effect are present in the humanheart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:43:03