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Titolo:
EFFECTS OF HALOPERIDOL AND SCH-23390 ON ACOUSTIC STARTLE IN ANIMALS DEPLETED OF DOPAMINE AS NEONATES - IMPLICATIONS FOR NEUROPSYCHIATRIC SYNDROMES
Autore:
SCHWARZKOPF SB; BRUNO JP; MITRA T; ISON JR;
Indirizzi:
UNIV ROCHESTER,DEPT BRAIN & COGNIT SCI,171 MELIORA HALL ROCHESTER NY 14627 UNIV ROCHESTER,DEPT PSYCHIAT ROCHESTER NY 14627 UNIV ROCHESTER,CTR VISUAL SCI ROCHESTER NY 14627 OHIO STATE UNIV,DEPT PSYCHIAT COLUMBUS OH 43210 OHIO STATE UNIV,DEPT PSYCHOL COLUMBUS OH 43210
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 123, anno: 1996,
pagine: 258 - 266
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE SCHIZOPHRENIC-PATIENTS; PREPULSE INHIBITION; BRAIN DOPAMINE; CEREBROSPINAL-FLUID; RATS; RECEPTOR; SENSORIMOTOR; D1; BEHAVIOR; REFLEX;
Keywords:
NEONATAL; DOPAMINE; D-1/D-2 RECEPTORS; ACOUSTIC STARTLE REFLEX; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Schwarzkopf et al., "EFFECTS OF HALOPERIDOL AND SCH-23390 ON ACOUSTIC STARTLE IN ANIMALS DEPLETED OF DOPAMINE AS NEONATES - IMPLICATIONS FOR NEUROPSYCHIATRIC SYNDROMES", Psychopharmacology, 123(3), 1996, pp. 258-266

Abstract

Animals depleted of dopamine (DA) in the neonatal period and tested in adulthood exhibit some similarities to patients with schizophrenia, including increased sensitivity to DA agonists, altered sensitivity toDA receptor antagonists, and abnormalities of the acoustic startle response (ASR). In this study, we examined the contributions of D-1-likeand D-2-like DA receptors to ASR measures in animals depleted of DA as neonates, Male rat pups received intracerebroventricular injections of 6-hydroxydopamine (DA depleted) or its vehicle (controls) at 3 daysof age. Animals underwent startle testing as adults (60-75 days of age) after administration of DA antagonists (haloperidol: 0.1 or 0.3 mg/kg, SCH 23390: 0.01 or 0.05 mg/kg) with and without DA agonist administration (apomorphine 0.5 mg/kg). ASR amplitude and prepulse inhibition(PPI: percentage decrease in startle amplitude due to a low intensityprepulse) were measured. DA depleted animals showed increased ASR amplitude and reduced PPI compared to controls, Administration of D-1-like or D-2-like DA antagonists significantly reduced overall ASR and increased PPI in both control and DA depleted animals, with DA depleted animals showing a relatively greater sensitivity to the D-1-like antagonist SCH 23390. Findings are discussed in terms of the role of residual DA in mediating ASR phenomena in depleted animals, differences between D-1/D-2 DA receptor mediation of ASR compared to other behaviors inDA depleted animals, and potential implications for neuropsychiatric syndromes such as schizophrenia.

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Documento generato il 22/01/20 alle ore 09:25:30