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Titolo:
MORPHINE-WITHDRAWAL ALTERS ANTERIOR-PITUITARY HORMONE-SECRETION, BRAIN ENDOPEPTIDASE ACTIVITY AND BRAIN MONOAMINE METABOLISM IN THE RAT
Autore:
IDANPAANHEIKKILA JJ; RAUHALA P; TUOMINEN RK; TUOMAINEN P; ZOLOTOV N; MANNISTO PT;
Indirizzi:
HELSINKI UNIV,DEPT PHARMACOL & TOXICOL,INST BIOMED,POB 8 SF-00014 HELSINKI FINLAND
Titolo Testata:
Pharmacology & toxicology
fascicolo: 3, volume: 78, anno: 1996,
pagine: 129 - 135
SICI:
0901-9928(1996)78:3<129:MAAHB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; PROLINE CLEAVING ENZYME; MEDIAN-EMINENCE; IMMOBILIZATION STRESS; RESTRAINT STRESS; PROLACTIN LEVELS; PORCINE PLASMA; TSH SECRETION; ETHER STRESS; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Idanpaanheikkila et al., "MORPHINE-WITHDRAWAL ALTERS ANTERIOR-PITUITARY HORMONE-SECRETION, BRAIN ENDOPEPTIDASE ACTIVITY AND BRAIN MONOAMINE METABOLISM IN THE RAT", Pharmacology & toxicology, 78(3), 1996, pp. 129-135

Abstract

Rats were made tolerant to morphine by a 5-day regimen with increasing doses. The time course of changes in serum anterior pituitary hormone levels, brain endo- and exopeptidase activity, levels of brain biogenic amines and body weight were studied during abrupt morphine withdrawal. Cold stimulated secretion of thyrotropin and the secretion of growth hormone were both decreased whereas that of prolactin was increased. In the hypothalamus both prolyl endopeptidase and dipeptidyl peptidase IV activities were concomitantly increased. The hypothalamic 5 hydroxyindole acetic acid levels were also increased. Changes in hormone secretion, peptidase activity and monoamine turnover had returned to baseline levels by 92 hr. Our results indicate that morphine withdrawaland the associated stress produce alterations in anterior pituitary thyrotropin and growth hormone secretion. Concomitant increases in hypothalamic prolyl endopeptidase and dipeptidyl peptidase activities may contribute to these changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:47:17