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Titolo:
CHARACTERIZATION OF EPSTEIN-BARR VIRUS-INFECTED CELLS IN BENIGN LYMPHADENOPATHY OF PATIENTS SEROPOSITIVE FOR HUMAN-IMMUNODEFICIENCY-VIRUS
Autore:
BROUSSET P; SCHLAIFER D; RODA D; MASSIP P; MARCHOU B; DELSOL G;
Indirizzi:
CHU PURPAN,ANAT PATHOL LAB,PL DOCTEUR BAYLAC F-31059 TOULOUSE FRANCE CHU PURPAN,DEPT PATHOL TOULOUSE FRANCE CHU RANGUEIL,DEPT HEMATOL F-31054 TOULOUSE FRANCE CHU PURPAN,DEPT HEMATOL TOULOUSE FRANCE
Titolo Testata:
Human pathology
fascicolo: 3, volume: 27, anno: 1996,
pagine: 263 - 268
SICI:
0046-8177(1996)27:3<263:COEVCI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; HOMOSEXUAL MEN; EXPRESSION; GENE; TRANSPLANTATION; SPECIMENS; ANTIBODY; THERAPY; LATENCY;
Keywords:
EPSTEIN-BARR VIRUS, HUMAN IMMUNODEFICIENCY VIRUS, LYMPHADENOPATHY; LATENCY; LYMPHOMAGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P. Brousset et al., "CHARACTERIZATION OF EPSTEIN-BARR VIRUS-INFECTED CELLS IN BENIGN LYMPHADENOPATHY OF PATIENTS SEROPOSITIVE FOR HUMAN-IMMUNODEFICIENCY-VIRUS", Human pathology, 27(3), 1996, pp. 263-268

Abstract

The authors investigated 25 benign lymph nodes in patients infected with the human immunodeficiency virus (HIV) by in situ hybridization (ISH) and immunohistochemistry (IHC) to detect and characterize the Epstein-Barr virus (EBV)-infected cells. After ISH, 22 lymph nodes were found to contain various numbers of Epstein-Barr-encoded RNA (EBER)-positive cells. Most of these cells were B cells. In six lymph nodes with numerous EBV-infected cells, EBNA2-positive/LMP1-positive lymphoblastoid cells were detected by IHC. Exceptional cells (in two specimens) were positively labeled with anti-Z Epstein-Barr replicative activator (ZEBRA) antibody or BamHI Left Frame 1/Not I (BHLF1/Not I) probes, indicating that EBV replication is not enhanced in the lymphocytes. In normal conditions (healthy individuals), small lymphocytes that express arestricted pattern of viral genes do escape immune response, whereas lymphoblastoid cells do not. Thus, impaired immune system may account for the late proliferation of lymphoblastoid cells (Epstein-Barr nuclear antigen [EBNA]2 positive/latent membrane protein [LMP]1 positive) in HIV-infected patients, and could explain why EBV-driven, acquired inmunodeficiency syndrome (AIDS)-related, non-Hodgkin's lymphoma occur more frequently in patients with low CD4-positive T cells. (C) 1996 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:07:58