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Titolo:
MODULATION OF CATECHOLAMINE STORAGE AND RELEASE BY THE PITUITARY INTERRENAL AXIS IN THE RAINBOW-TROUT, ONCORHYNCHUS-MYKISS
Autore:
REID SG; VIJAYAN MM; PERRY SF;
Indirizzi:
UNIV OTTAWA,DEPT BIOL,30 MARIE CURIE OTTAWA ON K1N 6N5 CANADA UNIV OTTAWA,DEPT BIOL OTTAWA ON K1N 6N5 CANADA
Titolo Testata:
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
fascicolo: 8, volume: 165, anno: 1996,
pagine: 665 - 676
SICI:
0174-1578(1996)165:8<665:MOCSAR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENYLETHANOLAMINE N-METHYLTRANSFERASE; ADRENERGIC SIGNAL-TRANSDUCTION; CORTISOL-INDUCED CHANGES; METHYL TRANSFERASE PNMT; CHROMAFFIN TISSUE; SALMO-GAIRDNERI; BETA-ADRENOCEPTORS; GADUS-MORHUA; PLASMA-CATECHOLAMINES; SALVELINUS-FONTINALIS;
Keywords:
CATECHOLAMINES; CORTISOL; CHROMAFFIN CELLS; ADRENOCORTICOTROPIC HORMONE; RAINBOW TROUT, ONCORHYNCHUS MYKISS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Reid et al., "MODULATION OF CATECHOLAMINE STORAGE AND RELEASE BY THE PITUITARY INTERRENAL AXIS IN THE RAINBOW-TROUT, ONCORHYNCHUS-MYKISS", Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 165(8), 1996, pp. 665-676

Abstract

This study examined the effects of pituitary-interrenal hormones on catecholamine storage and release in the rainbow trout Oncorhynchus mykiss. An extract of trout pituitary elicited the release of adrenaline,but not noradrenaline, using an in situ perfusion preparation. A variety of doses of adrenocorticotropic hormone (2-2000 mU) caused the release of both catecholamines in situ which was unaffected by pre-treatment with the ganglion blocker, hexamethonium, or the serotonergic receptor antagonist, methysergide, but was abolished in calcium-free media. Intra-arterial injections of adrenocorticotrophic hormone in vivo caused an elevation of plasma adrenaline but not noradrenaline levels. Injections of cortisol in situ did not elicit catecholamine release. Trout given an intraperitoneal implant of cortisol (50 mg . kg(-1) body weight) had significantly higher plasma cortisol concentrations when compared to controls after 7 days of implantation. Increases in the levels of stored catecholamines were observed in various regions of the kidney and posterior cardinal vein following 3 and 7 days of cortisol treatment. The ability of the chromaffin cells to release catecholamines in response to cholinergic stimulation was assessed in situ after 7 days of treatment. Basal (non-stimulated) adrenaline outflowing perfusate levels were greater in the cortisol-treated fish. Cortisol treatment increased the responsiveness of the catecholamine release process to low doses of the cholinoceptor agonist carbachol. Three or 7 days ofcortisol treatment did not alter the in vitro activity of the enzyme phenylethanolamine-N-methyltransferase. The results of this study demonstrate that interactions within the pituitary-adrenal axis can influence both catecholamine storage and release in the rainbow trout.

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Documento generato il 29/10/20 alle ore 00:16:20