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Titolo:
EXPANDING THE DONOR POOL - USE OF MARGINAL DONORS FOR SOLID-ORGAN TRANSPLANTATION
Autore:
ALEXANDER JW; ZOLA JC;
Indirizzi:
UNIV CINCINNATI,COLL MED,DEPT SURG,221 BETHESDA AVE CINCINNATI OH 45267
Titolo Testata:
Clinical transplantation
fascicolo: 1, volume: 10, anno: 1996,
parte:, 1
pagine: 1 - 19
SICI:
0902-0063(1996)10:1<1:ETDP-U>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC LIVER-TRANSPLANTATION; HEART-BEATING DONORS; RENAL-TRANSPLANTATION; CARDIAC TRANSPLANTATION; KIDNEY-TRANSPLANTATION; GRAFT FUNCTION; SELECTION CRITERIA; POSITIVE DONORS; ELDERLY DONORS; DETRIMENTAL FACTOR;
Keywords:
ALLOGENEIC ORGAN TRANSPLANTATION; ORGAN PROCUREMENT; ORGAN DONORS; KIDNEY TRANSPLANTATION; HEART TRANSPLANTATION; LIVER TRANSPLANTATION; ORGAN STORAGE; INFECTIOUS DISEASE; AGE FACTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Alexander e J.C. Zola, "EXPANDING THE DONOR POOL - USE OF MARGINAL DONORS FOR SOLID-ORGAN TRANSPLANTATION", Clinical transplantation, 10(1), 1996, pp. 1-19

Abstract

Organ transplantation has become a viable treatment for an increasingnumber of patients suffering from irreversible organ failure. In response to the steeply rising demand for tansplantation, both the number of transplant centers and the number of patients on waiting lists havegrown rapidly. Because organ donation has not kept pace with demand, each year a greater number of patients die while awaiting donor organs. (About 9% of all patients on the list in 1993 but not transplanted died. Death rates were highest, 19% and 16% respectively, for patients awaiting hearts and livers. ) Among the factors contributing to the organ shortage are cultural and psychological barriers to donation and missed opportunities to request donation. An accompanying diminution in traumatic deaths of potential young donors has made older and other marginal, or higher-risk, donors the focus of studies on expansion of the donor pool. The studies reviewed herein evaluate donor risk factors such as age, disease (including infection), obesity, cold ischemia time, suboptimal organ function, and nontraumatic causes of death. Overall, broadened criteria for acceptable donor kidneys, hearts, and liversappear to lessen graft survival rates somewhat compared with rates for ideal donor organs. Nonetheless, use of higher-risk organs allows lifesaving transplants that could not otherwise be performed and resultsin acceptable prognoses for survival. Further research is needed to identify better tests for evluating donor organs, provide longer-term follow-up of recipients of higher-risk organs, and develop alternative means to fill the donor-organ shortfall.

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Documento generato il 29/05/20 alle ore 19:08:07