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Titolo:
CANDIDA-GLABRATA - IN-VITRO SUSCEPTIBILITY OF 84 ISOLATES TO 8 ANTIFUNGAL AGENTS
Autore:
ARIAS A; AREVALO MP; ANDREU A; RODRIGUEZ C; SIERRA A;
Indirizzi:
UNIV LA LAGUNA,FAC MED,CATEDRA MED PREVENT & SALUD PUBL E-38071 LA LAGUNA SANTA CRUZ TENE SPAIN
Titolo Testata:
Chemotherapy
fascicolo: 2, volume: 42, anno: 1996,
pagine: 107 - 111
SICI:
0009-3157(1996)42:2<107:C-ISO8>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO SUSCEPTIBILITY; BROTH MACRODILUTION; AMPHOTERICIN-B; ITRACONAZOLE; KETOCONAZOLE; 5-FLUOROCYTOSINE; FLUCONAZOLE;
Keywords:
ANTIFUNGAL AGENT; BROTH-DILUTION; CANDIDA GLABRATA; MICROPLATE METHOD; SUSCEPTIBILITY TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Arias et al., "CANDIDA-GLABRATA - IN-VITRO SUSCEPTIBILITY OF 84 ISOLATES TO 8 ANTIFUNGAL AGENTS", Chemotherapy, 42(2), 1996, pp. 107-111

Abstract

The in vitro susceptibility of 84 isolates of Candida glabrata from patients treated at the University Hospital of the Canary islands to eight antifungal agents (amphotericin B, itraconazole, fluconazole, miconazole, clotrimazole, tioconazole and econazole) has been studied using the broth dilution micro-method. Among the eight antifungal agents tested, the smaller geometric mean corresponded to tioconazole, econazole, clotrimazole and miconazole. In contrast with fluconazole, a greater geometric mean has been achieved. All the C. glabrata isolates tested were sensitive to concentrations of 3. 125 mu g/ml of clotrimazole and miconazole, 6.25 mu g/ml of amphotericin and ketoconazole. Concentrations of 12.5 mu g/ml were needed to obtain 100% inhibition of isolates for econazole and tioconazole and concentrations of 25 and 50 mu g/ml, respectively for itraconazole and fluconazole. Among our C. glabrata isolates, 2.4% were found to be resistant to amphotericin B. For fluconazole and itraconazole, 19.1% and 7.9% of isolates, respectively,were resistant. With reference to imidazoles, we obtained 2.4% and 3.6% resistance for tioconazole and econazole, respectively. No isolateswere found to be resistant to ketoconazole, miconazole and clotrimazole. The results have shown a high activity of amphotericin B and itraconazole, observing a similar response with the five imidazole antifungals tested. The highest rate of resistance was found when fluconazole was used.

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Documento generato il 01/12/20 alle ore 10:52:48