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Titolo:
ANTIGENOTOXIC ACTIVITIES OF CHITIN AND CHITOSAN AS ASSAYED BY SISTER-CHROMATID EXCHANGE
Autore:
OHE T;
Indirizzi:
KYOTO WOMENS UNIV,DEPT FOOD & NUTR SCI,HIGASHIYAMA KU,KITAHIYOSHI CHOKYOTO 605 JAPAN
Titolo Testata:
Science of the total environment
fascicolo: 1, volume: 181, anno: 1996,
pagine: 1 - 5
SICI:
0048-9697(1996)181:1<1:AAOCAC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY FIBER; HYDROPHOBIC MUTAGEN; INVITRO BINDING; ADSORPTION; CANCER; WATER;
Keywords:
CHITIN; CHITOSAN; ANTIGENOTOXIC ACTIVITY; SISTER CHROMATID EXCHANGE ASSAY; HYDROPHILIC MUTAGEN; HYDROPHOBIC MUTAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T. Ohe, "ANTIGENOTOXIC ACTIVITIES OF CHITIN AND CHITOSAN AS ASSAYED BY SISTER-CHROMATID EXCHANGE", Science of the total environment, 181(1), 1996, pp. 1-5

Abstract

The antigenotoxic activities of chitin and chitosan were studied using sister chromatid exchange assay by examining the adsorption of four kinds of mutagens. These two dietary animal fibers showed similar patterns in reducing the genotoxicity of aqueous solutions of the hydrophobic mutagens, 4-nitroquinoline-N-oxide and dinitropyrene, in distilledwater. Under similar conditions, the antigenotoxic activities of chitin and chitosan for mitomycin C were 87 and 0%, and those for adriamycin were 47 and 78%, respectively. In addition, the antigenotoxic activity of both fibers for MMC was affected by the pH value of the aqueoussolution between 2.5 and 7.2, but that of ADM was not. The results demonstrate that chitin and chitosan may have protective effects againstenvironmental mutagens by adsorbing them in ionic and nonionic solutions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:24:11