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Titolo:
LUNG-FUNCTION IN HEALTHY NEVER SMOKING ADULTS - REFERENCE VALUES AND LOWER LIMITS OF NORMAL OF A SWISS POPULATION
Autore:
BRANDLI O; SCHINDLER C; KUNZLI N; KELLER R; PERRUCHOUD AP; LEUENBERGER P; ACKERMANNLIEBRICH U; ALEAN P; BLASER K; BOLOGNINI G; BONGARD JP; BRAUN P; BRON C; BRUTSCHE M; DEFILA C; DOMENIGHETTI G; ELASSER S; GRIZE L; GULDIMANN P; HUFSCHMID P; KARRER W; KELLERWOSSIDLO H; LUTHY JC; MARTIN BW; MEDICI T; MONN C; PEETERS AG; RADAELLI A; SCHWARTZ J; SOLARI G; SCHONI M; TSCHOPP JM; VILLIGER B; WUTHRICH B; ZELLWEGER JP; ZEMP E;
Indirizzi:
ZURCHER HOHENKLIN CH-8639 FALTIGBERG SWITZERLAND UNIV BASEL,INST SOCIAL & PREVENT MED CH-4003 BASEL SWITZERLAND PNEUMOL CLIN BARMELWEID AARAU SWITZERLAND UNIV HOSP,DEPT INTERNAL MED,DIV PNEUMOL BASEL SWITZERLAND
Titolo Testata:
Thorax
fascicolo: 3, volume: 51, anno: 1996,
pagine: 277 - 283
SICI:
0040-6376(1996)51:3<277:LIHNSA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPIROMETRY; TESTS;
Keywords:
LUNG FUNCTION; SPIROMETRY; REFERENCE VALUES; SMOKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
O. Brandli et al., "LUNG-FUNCTION IN HEALTHY NEVER SMOKING ADULTS - REFERENCE VALUES AND LOWER LIMITS OF NORMAL OF A SWISS POPULATION", Thorax, 51(3), 1996, pp. 277-283

Abstract

Background - Reference values and definitions of ''normal'' are prerequisites for population screening and classification of lung diseases. The aim of this study was to calculate reference values for never smoking Caucasian adults. Methods - In the SAPALDIA cross sectional studyrespiratory health was assessed in a random sample of 9651 subjects, aged 18-60 years, from eight areas of Switzerland. Lung function was measured according to ATS criteria including quality control. In 3157 healthy never smoking adults without respiratory symptoms the mean values and fifth percentiles of lung function variables were calculated. For each sex, logarithms of lung function were regressed against age, age squared, and the logarithm of height. Residuals were used to estimate fifth percentiles across the age range using a technique not requiring normality or homoscedasticity of residuals. Results - Most lung function variables were non-linear with age and showed an increase in early adulthood and an accelerated decline thereafter. The reference values for forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)) were higher than those of the European Community forCoal and Steel and those from North America. The prediction equationsfor lower fifth percentile values defined a stable proportion of subjects out Switzerland side this limit whereas alternative methods for estimating the fifth percentile showed a loss of sensitivity with age. Conclusions - The reference equations for mean values of spirometric indices and their lower fifth percentiles gave an improved and unbiasedlower limit of normal. The higher mean values may in part be due to the strictly selected population, quality control procedures, cohort effects, and altitude, and are not explained by the statistical model used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:50:06