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Titolo:
A COMPUTATIONAL MODEL OF VISUAL HALLUCINATIONS IN MIGRAINE
Autore:
REGGIA JA; MONTGOMERY D;
Indirizzi:
UNIV MARYLAND,DEPT COMP SCI,AV WILLIAMS BLDG COLLEGE PK MD 20742 UNIV MARYLAND,INST ADV COMP STUDIES COLLEGE PK MD 20742 UNIV MARYLAND,SCH MED,DEPT NEUROL COLLEGE PK MD 20742
Titolo Testata:
Computers in biology and medicine
fascicolo: 2, volume: 26, anno: 1996,
pagine: 133 - 141
SICI:
0010-4825(1996)26:2<133:ACMOVH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
WAVES; EGGS;
Keywords:
MIGRAINE; NEURAL MODEL; CORTICAL SPREADING DEPRESSION; REACTION-DIFFUSION MODEL; VISUAL HALLUCINATIONS; COMPUTATIONAL MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Reggia e D. Montgomery, "A COMPUTATIONAL MODEL OF VISUAL HALLUCINATIONS IN MIGRAINE", Computers in biology and medicine, 26(2), 1996, pp. 133-141

Abstract

Cortical spreading depression is a wave of electrical and biochemicalchanges that spreads across the cerebral cortex. It has been hypothesized to be an important underlying cause of the visual disturbances occurring during the migraine aura, but this is difficult to test in animals or humans. We created a computational model of cortical spreadingdepression and found that during the wave of biochemical changes the spatial pattern of neural activity broke up into irregular patterns oflines and small patches of highly activated elements. The corresponding visual disturbances that would be produced by these patterns of neural activity resemble the hallucinations reported during the migraine aura, providing strong support for the cortical spreading depression hypothesis of migraine. The model also makes the testable prediction that these hallucinations move at an exponentially increasing speed across the visual field.

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Documento generato il 31/03/20 alle ore 16:31:26