Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANGIOTENSIN-CONVERTING ENZYME INHIBITION-INDUCED CHANGES IN HIPPURATERENOGRAPHY AND RENAL-FUNCTION IN RENOVASCULAR HYPERTENSION
Autore:
VISSCHER CA; DEZEEUW D; DEJONG PE; PIERS DA; BEEKHUIS H; GROOTHUIS GMM; HUISMAN RM;
Indirizzi:
UNIV GRONINGEN HOSP,DEPT MED,DIV NEPHROL,GRONINGEN INST DRUG STUDIES,POB 30001 9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT MED,DIV NEPHROL,GRONINGEN INST DRUG STUDIES 9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT NUCL MED & PHARMACOL,GRONINGEN INST DRUG STUDIES 9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT PHARMACOTHERAPEUT,GRONINGEN INST DRUG STUDIES 9700 RB GRONINGEN NETHERLANDS
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 3, volume: 37, anno: 1996,
pagine: 482 - 488
SICI:
0161-5505(1996)37:3<482:AEICIH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY STENOSIS; CAPTOPRIL RENOGRAPHY; ACE-INHIBITION; SCINTIGRAPHY; DIAGNOSIS; DOGS; 2-KIDNEY; FLOW;
Keywords:
RENOVASCULAR HYPERTENSION; GLOMERULAR FILTRATION RATE; RADIOISOTOPE RENOGRAPHY; RENAL ARTERY STENOSIS; RENIN-ANGIOTENSIN SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Visscher et al., "ANGIOTENSIN-CONVERTING ENZYME INHIBITION-INDUCED CHANGES IN HIPPURATERENOGRAPHY AND RENAL-FUNCTION IN RENOVASCULAR HYPERTENSION", The Journal of nuclear medicine, 37(3), 1996, pp. 482-488

Abstract

We studied the mechanism of angiotensin-converting enzyme (ACE) inhibition-induced changes in hippurate renography of the poststenotic kidney. Methods: Ten male mongrel dogs, six with unilateral and four with bilateral renal artery stenosis, were equipped with renal artery bloodflow probes and catheters in the aorta, atrium and both renal veins. Results: Enalaprilat (10 mg intravenously) in conscious dogs with renal artery stenoses produced changes in ail stenotic (n = 11) but not innonstenotic kidney I-123-hippurate renograms (n = 6), Renographic changes correlated significantly with initiation of intrarenal I-131-hippurate retention, a decrease in mean arterial pressure (MAP), renal extraction of I-131-hippurate and I-125-iothalamate (r = 0.68, r = 0.62, r = 0.84, r = 0.83, respectively) but not with renal blood flow changes (r = 0.34), Furthermore, renal uptake of I-131-hippurate and I-125-iothalamate decreased in stenotic kidneys with a grade II renogram (-52+/- 11% and -79 +/- 6%, respectively), Iodine-125-hippurate autoradiograms of stenotic kidneys during ACE inhibition showed tracer retention mainly in the proximal tubular cells. Results during osmotic diuresis supported our findings. Conclusion: Angiotensin-converting enzyme inhibition-induced hippurate retention curves of poststenotic kidneys appear to result from a sequence of events, A decrease in MAP combined with efferent vasodilation leads to a decrease in intraglomerular capillary pressure. This decrease in pressure causes a decease in glomerular filtration rate and proximal tubular urine flow, This decrease in turn hampers tubular hippurate transit and transport across the luminal membrane, leading to intrarenal hippurate retention and, in more severe cases, decreased renal hippurate uptake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:30:13