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Titolo:
EFFECTS OF DIFFERENT CONGESTION PRESSURES ON THE DIAMETER OF THE DORSAL HAND VEIN AND ON ITS APPARENT SENSITIVITY TO NORADRENALINE
Autore:
ABDELMAWLA AH; LANGLEY RW; SZABADI E; BRADSHAW CM;
Indirizzi:
QUEENS MED CTR,DEPT PSYCHIAT,FLOOR A,S BLOCK NOTTINGHAM NG7 2UH ENGLAND QUEENS MED CTR,DEPT PSYCHIAT NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 3, volume: 353, anno: 1996,
pagine: 324 - 327
SICI:
0028-1298(1996)353:3<324:EODCPO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPONSIVENESS;
Keywords:
DOSE-RESPONSE CURVE; NORADRENALINE; DORSAL HAND VEIN; HEALTHY VOLUNTEERS; CONGESTION PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A.H. Abdelmawla et al., "EFFECTS OF DIFFERENT CONGESTION PRESSURES ON THE DIAMETER OF THE DORSAL HAND VEIN AND ON ITS APPARENT SENSITIVITY TO NORADRENALINE", Naunyn-Schmiedeberg's archives of pharmacology, 353(3), 1996, pp. 324-327

Abstract

We have measured the diameter of the human dorsal hand vein (DHV) in situ and compared the venoconstrictor dose-response curves to locally infused noradrenaline at different venous congestion pressures using the DHV compliance technique. Congestion pressure was defined as the inflation pressure of a sphygmomanometer cuff on the ipsilateral upper arm. Male healthy volunteers (20-45 years) participated in two experimental sessions. In Session I, DHV diameter was measured at congestion pressures of 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70 mmHg. In Session II, venoconstrictor dose-response curves to six doses (0.1-33.33 ng min(-1)) of (-)noradrenaline acid tartrate were established at congestion pressures 30 and 45 mmHg. DHV diameter increased as a function of congestion pressure. The rate of increase in DHV diameter (mm/5 mmHg) declined at higher values of congestion pressure (e.g. 0.14mm/5 mmHg between 20 and 45 mmHg, and 0.04mm/5 mmHg between 45 and 70 mmHg). Noradrenaline was less potent at 45 mmHg than at 30 mmHg. Mean log ED(50) was significantly greater at 45 mmHg than at 30 mmHg congestion pressure, while mean E(max) did not differ at the two congestion pressures. The geometric mean ED(50) was approximately 195% greater at 45 mmHg than at 30 mmHg. These results show that DHV diameter is positively related to congestion pressure, and that as the congestion pressure increases, the apparent sensitivity of the vein to the venoconstrictor effect of noradrenaline decreases. This latter finding is consistent with the physiological antagonism between congestion-induced venodilatation and noradrenaline-evoked venoconstriction. It is recommended that a standard congestion pressure is used in order to facilitate the comparison of results obtained in different laboratories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:21:43