Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A NEW LONG-ACTING FORMULATION OF THE LUTEINIZING-HORMONE-RELEASING HORMONE ANALOG, GOSERELIN - RESULTS OF STUDIES IN PROSTATE-CANCER
Autore:
DEBRUYNE FM; DIJKMAN GA; LEE DCH; WITJES WPJ;
Indirizzi:
UNIV NIJMEGEN HOSP,GEERT GROOTEPLEIN 16,POB 9101 6500 NB NIJMEGEN NETHERLANDS ST IGNATIUS HOSP BREDA NETHERLANDS ZENECA PHARMACEUT MACCLESFIELD CHESHIRE ENGLAND
Titolo Testata:
The Journal of urology
fascicolo: 4, volume: 155, anno: 1996,
pagine: 1352 - 1354
SICI:
0022-5347(1996)155:4<1352:ANLFOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LHRH-ANALOG; ZOLADEX; ORCHIECTOMY; CARCINOMA;
Keywords:
PROSTATE; PROSTATIC NEOPLASMS; TESTOSTERONE; GOSERELIN; DELAYED-ACTION PREPARATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
F.M. Debruyne et al., "A NEW LONG-ACTING FORMULATION OF THE LUTEINIZING-HORMONE-RELEASING HORMONE ANALOG, GOSERELIN - RESULTS OF STUDIES IN PROSTATE-CANCER", The Journal of urology, 155(4), 1996, pp. 1352-1354

Abstract

Purpose: To assess the pharmacodynamic equivalence of the new 10.8 mg, goserelin depot with the current 3.6 mg. depot 3 studies were performed in patients with advanced prostate cancer. Materials and Methods: In 2 comparative studies 160 patients were randomized for dosing every12 weeks using the 10.8 mg, depot or every 4 weeks using the 3.6 mg. depot. In the noncomparative study 35 patients received the 10.8 mg. depot. Blood sampling for serum testosterone and evaluation of toxicitywas done during the 48-week study period. Results: Serum testosteroneprofiles of the 10.8 and 3.6 mg. goserelin depots were similar with testosterone levels decreasing into the castrate range by day 21 after depot administration. The safety profile of 10.8 mg. goserelin is comparable to that of the current monthly depot with the main side effectsrelated to androgen deprivation. Conclusions: The new long acting depot was pharmacologically equivalent, and well tolerated locally and systemically, and will offer added convenience to patients and health care personnel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 10:21:42