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Titolo:
EFFECT OF CLONIDINE ON THE HUMAN ACOUSTIC STARTLE REFLEX
Autore:
KUMARI V; COTTER P; CORR PJ; GRAY JA; CHECKLEY SA;
Indirizzi:
UNIV LONDON,INST PSYCHIAT,DE CRESPIGNY PK LONDON SE5 8AF ENGLAND UNIV LONDON,INST PSYCHIAT LONDON SE5 8AF ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 123, anno: 1996,
pagine: 353 - 360
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; ANTICIPATORY ANXIETY; HABITUATION; ANTAGONISTS; AGONISTS; PARADIGM;
Keywords:
CLONIDINE; ACOUSTIC STARTLE REFLEX; EYEBLINK; HABITUATION; CENTRAL ALPHA(2) ADRENOCEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
V. Kumari et al., "EFFECT OF CLONIDINE ON THE HUMAN ACOUSTIC STARTLE REFLEX", Psychopharmacology, 123(4), 1996, pp. 353-360

Abstract

The present study investigated in healthy human volunteers whether clonidine reduced the amplitude of the acoustic startle reflex and whether this effect, if found, was due to an accelerated rate of habituation. Subjects were presented with startle-eliciting noise-bursts after intravenous (iv) infusion of clonidine (1.5 mu g/kg) and saline on separate days. Clonidine significantly reduced the amplitude of the acoustic startle reflex (as indexed by the eyeblink component) relative to the saline treated condition. This effect was neither due to an accelerated rate of habituation of the startle reflex nor to the sedative effect of clonidine. These findings complement an earlier report (Morgan et al. 1993) that yohimbine augments the amplitude of the startle reflex in man. Taken together, the two reports indicate a new model for the clinical investigation of central alpha(2) adrenoceptor function in humans.

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Documento generato il 26/01/20 alle ore 10:14:12