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Titolo:
RISK-FACTORS FOR OROFACIAL AND LIMBTRUNCAL TARDIVE-DYSKINESIA IN OLDER PATIENTS - A PROSPECTIVE LONGITUDINAL-STUDY
Autore:
PAULSEN JS; CALIGIURI MP; PALMER B; MCADAMS LA; JESTE DV;
Indirizzi:
UNIV CALIF SAN DIEGO,3350 LA JOLLA VILLAGE DR,9-116-B SAN DIEGO CA 92161
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 123, anno: 1996,
pagine: 307 - 314
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; NEGATIVE SYMPTOMS; RATING-SCALE; PREVALENCE; ASSOCIATION; DISORDERS; SUBTYPES; DISEASE;
Keywords:
ALCOHOL DEPENDENCE; MOVEMENT DISORDERS; SCHIZOPHRENIA; ALZHEIMERS DISEASE; NEUROLEPTICS; AGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Paulsen et al., "RISK-FACTORS FOR OROFACIAL AND LIMBTRUNCAL TARDIVE-DYSKINESIA IN OLDER PATIENTS - A PROSPECTIVE LONGITUDINAL-STUDY", Psychopharmacology, 123(4), 1996, pp. 307-314

Abstract

Although there is a consensus that orofacial and limbtruncal subtypesof tardive dyskinesia (TD) exist and may represent distinct pathophysiologic entities, few studies have examined the incidence of and risk factors associated with the development of these TD subtypes. Two hundred and sixty-six middle-aged and elderly outpatients with a median duration of 21 days of total lifetime neuroleptic exposure at study entry were evaluated at 1- to 3-month intervals. Using ''mild'' dyskinesiain any part of the body for diagnosis of TD, the cumulative incidenceof orofacial TD was 38.5 and 65.7% after and 2 years, respectively, whereas that of limbtruncal TD was 18.6 and 32.6% after 1 and 2 years. Preclinical dyskinesia was predictive of both orofacial and limbtruncal TD. History of alcohol abuse or dependence was a significant predictor of orofacial TD only whereas tremor was a significant predictor of limbtruncal TD only. Findings support suggestions that orofacial and limbtruncal TD may represent specific subsyndromes with different risk factors.

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Documento generato il 04/04/20 alle ore 08:37:07