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Titolo:
THE INHIBITORY EFFECT OF MEDROXYPROGESTERONE ACETATE ON STEROID SULFATASE IN HUMAN UTERINE ENDOMETRIAL CANCER-CELLS
Autore:
YAMAMOTO T; YOKOTA K; URABE M; KITAWAKI J; HONJO H;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,KAMIKYO KU KYOTO 602JAPAN
Titolo Testata:
Endocrine-related cancer
fascicolo: 4, volume: 3, anno: 1996,
pagine: 337 - 340
SICI:
1351-0088(1996)3:4<337:TIEOMA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamamoto et al., "THE INHIBITORY EFFECT OF MEDROXYPROGESTERONE ACETATE ON STEROID SULFATASE IN HUMAN UTERINE ENDOMETRIAL CANCER-CELLS", Endocrine-related cancer, 3(4), 1996, pp. 337-340

Abstract

The activity of estrone sulfatase (E(1)SF), which converts estrone sulfate to estrone, In uterine endometrial cancer tissue is remarkably high compared with endometrial tissues, and this is assumed to contribute to the growth of this tumor. Thus, in this study, in order to screen drugs for sulfatase inhibitor activity, the inhibitory effect of medroxyprogesterone acetate (MPA; which is widely used for advanced or recurrent endometrial cancer) on E(1)SF activity and steroid sulfatase (STS) gene expression in endometrial cancer cells was examined and compared with danazol (DZ). MPA and DZ were shown to inhibit E(1)SF activity dose-dependently in the established endometrial cancer cell lines (Ishikawa and HEC-59 strains). These drugs (10(-8) M) also inhibited the expression of STS mRNA, and this inhibition of STS gene expression is considered to partly explain their inhibitory actions against STS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:14:00