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Titolo:
ERYTHROPOIETIN STIMULATES ATRIAL-NATRIURETIC-PEPTIDE SECRETION FROM ADULT-RAT CARDIAC ATRIUM
Autore:
PORAT O; NEUMANN D; ZAMIR O; NACHSHON S; FEIGIN E; COHEN J; ZAMIR N;
Indirizzi:
TEL AVIV UNIV,SACKLER FAC MED,DEPT PHYSIOL & PHARMACOL IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,DEPT PHYSIOL & PHARMACOL IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,DEPT HISTOL & CELL BIOL IL-69978 TEL AVIV ISRAEL HADASSAH UNIV HOSP,DEPT SURG IL-91240 JERUSALEM ISRAEL SHAARE ZADEK MED CTR,DEPT SURG JERUSALEM ISRAEL
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 3, volume: 276, anno: 1996,
pagine: 1162 - 1168
SICI:
0022-3565(1996)276:3<1162:ESASFA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT ERYTHROPOIETIN; PULMONARY-HYPERTENSION; ENDOTHELIAL-CELLS; ANF RELEASE; HYPOXIA; MYOCYTES; INVITRO; CALCIUM; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
O. Porat et al., "ERYTHROPOIETIN STIMULATES ATRIAL-NATRIURETIC-PEPTIDE SECRETION FROM ADULT-RAT CARDIAC ATRIUM", The Journal of pharmacology and experimental therapeutics, 276(3), 1996, pp. 1162-1168

Abstract

Hypoxia is a powerful stimulus for erythropoietin (EPO) secretion from the kidney and for atrial natriuretic peptide (ANP) secretion from atrial myocytes, EPO is involved in the long-term defense mechanism against hypoxia via stimulation of erythropoiesis. ANP is involved in theshort-term defense mechanism against hypoxia via improved pulmonary and heart functions, We investigated a possible interaction between these two hormones. We tested the hypothesis that EPO may stimulate ANP secretion from the cardiac atrium. This hypothesis was tested in two invitro models: isolated rat atrium and cultured adult atrial rat myocytes. Recombinant human EPO (5-10 units/ml) enhanced ANP secretion fromthe isolated atrium (by similar to 2-fold) within 10 min in a concentration-dependent manner. To define whether the action of EPO on ANP secretion is direct, we examined the effect of EPO on ANP release from adult rat cultured atrial myocytes. EPO failed to stimulate ANP secretion from cultured atrial myocytes, suggesting that EPO-induced ANP secretion is an indirect effect. Cyclooxygenase products (e.g., prostaglandins) and endothelin 1 were shown to be potent secretagogues of ANP from cardiac atrium. To test whether EPO-induced ANP secretion from isolated perfused atrium is mediated by cyclooxygenase products and/or endothelin, we used inhibitors of the enzyme cyclooxygenase (indomethacinor aspirin) and the endothelin receptor ET(A) subtype antagonist BQ123. EPO-stimulated ANP secretion was not affected by indomethacin (10(-4) M) or aspirin (10(-4) M), whereas BQ123 (10(-6) M) completely abolished EPO-stimulated ANP secretion from cardiac atrium. Our results expand our knowledge on the interaction between EPO and ANP hormonal systems and their possible role in the acute defense mechanism against hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:12:29