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Titolo:
REGULATORY MECHANISMS OF ANTITUMOR T-CELL RESPONSES IN THE TUMOR-BEARING STATE
Autore:
FUJIWARA H; HAMAOKA T;
Indirizzi:
OSAKA UNIV,SCH MED,BIOMED RES CTR,2-2 YAMADA OKA SUITA OSAKA 565 JAPAN
Titolo Testata:
Immunologic research
fascicolo: 4, volume: 14, anno: 1995,
pagine: 271 - 291
SICI:
0257-277X(1995)14:4<271:RMOATR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; LYMPHOCYTE MATURATION FACTOR; ANTIGEN-PRESENTING CELLS; STIMULATORY FACTOR NKSF; HAPTEN-REACTIVE HELPER; GROWTH FACTOR-BETA; IFN-GAMMA; HETERODIMERIC CYTOKINE; IMMUNOGENIC PEPTIDES; INTERFERON-GAMMA;
Keywords:
TUMOR-BEARING STATE; ANTITUMOR RESPONSE; IMMUNOSUPPRESSION; CYTOKINE NETWORK; INTERFERON-GAMMA; TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; TRANSFORMING GROWTH FACTOR-BETA; INTERLEUKIN-12;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
109
Recensione:
Indirizzi per estratti:
Citazione:
H. Fujiwara e T. Hamaoka, "REGULATORY MECHANISMS OF ANTITUMOR T-CELL RESPONSES IN THE TUMOR-BEARING STATE", Immunologic research, 14(4), 1995, pp. 271-291

Abstract

Tumor-bearing hosts develop antitumor immune responses. However, a number of immunosuppressive mechanisms come into operation with the progression of tumor growth. This article will review the observations regarding the modulation of antitumor immune responses in the tumor-bearing state, and consider the mechanisms underlying tumor-induced immune defects, especially in the light of the induction of an abnormal cytokine network. We will also describe the restoration of suppressed antitumor immune responses by administration of a particular cytokine, interleukin-12.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:16:22