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Titolo:
A MATERNAL RISK FACTOR FOR MOTHER-TO-CHILD HTLV-I TRANSMISSION - VIRAL ANTIGEN-PRODUCING CAPACITIES IN CULTURE OF PERIPHERAL-BLOOD AND BREAST-MILK CELLS
Autore:
YOSHINAGA M; YASHIKI S; OKI T; FUJIYOSHI T; NAGATA Y; SONODA S;
Indirizzi:
KAGOSHIMA UNIV,FAC MED,DEPT OBSTET & GYNECOL,8-35-1 SAKURAGAOKA KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT VIROL KAGOSHIMA 890 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 7, volume: 86, anno: 1995,
pagine: 649 - 654
SICI:
0910-5050(1995)86:7<649:AMRFFM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-I; POLYMERASE CHAIN-REACTION; LEUKEMIA-VIRUS; POSITIVE MOTHERS; COMMON MARMOSET; CARRIER MOTHERS; ANTIBODY; IDENTIFICATION; LYMPHOCYTES; INFECTION;
Keywords:
HTLV-I; MOTHER-TO-CHILD TRANSMISSION; HTLV-I ANTIGEN-POSITIVE CELLS; PERIPHERAL BLOOD AND BREAST MILK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Yoshinaga et al., "A MATERNAL RISK FACTOR FOR MOTHER-TO-CHILD HTLV-I TRANSMISSION - VIRAL ANTIGEN-PRODUCING CAPACITIES IN CULTURE OF PERIPHERAL-BLOOD AND BREAST-MILK CELLS", Japanese journal of cancer research, 86(7), 1995, pp. 649-654

Abstract

We examined the relationship between productivity of HTLV-I antigen-positive cells in cultured peripheral blood mononuclear cells (PBMC) and breast milk mononuclear cells (BMMC) and the incidence of mother-to-child transmission of HTLV-I. Among 61 cases of HTLV-I carrier mothers, 17 cases were revealed to produce large numbers of HTLV-I antigen-positive cells (high HTLV-I antigen-producing mothers) whose positive rate was 9.6% in PBMC and 10.2% in BMMC, while the remaining 44 cases produced small numbers of HTLV-I antigen-positive cells (low HTLV-I antigen-producing mothers) whose positive rate was 0.3% in PBMC and 0.5% in BMMC. The HTLV-I transmission rate among children born to the high HTLV-I antigen-producing mothers was 37.5% (6/16 children from 11 mothers), while that of the low HTLV-I antigen-producing mothers was 3.2% (1/31 children from 20 mothers). The transmission rate of HTLV-I was significantly different between high and low HTLV-I antigen-producing mothers (P < 0.05). However, there was no positive relationship between anti-HTLV-I antibody titers and productivity of HTLV-I antigen-positive cells (P=0.11). These results suggested that mother-to-child transmission of HTLV-I might be influenced by a maternally determined factor to produce HTLV-I antigen-positive cells in PBMC and BMMC of HTLV-I carrier mothers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:17:22