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Titolo:
MODULATION OF THE ANTITUMOR-ACTIVITY OF CISPLATIN ALONE AND IN COMBINATION WITH 5-FLUORO-2'-DEOXYURIDINE BY N-PHOSPHONACETYL-L-ASPARTATE INMURINE COLON-CARCINOMA NO-26
Autore:
VANLAAR JAM; MAYHEW EG; CAO S; DURRANI FA; PETERS GJ; RUSTUM YM;
Indirizzi:
ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT EXPTL THERAPEUT,ELM & CARLTON ST BUFFALO NY 14263 ROSWELL PK CANC INST,GRACE CANC DRUG CTR,DEPT EXPTL THERAPEUT BUFFALONY 14263 LIPOSOME CO PRINCETON NJ 08540 FREE UNIV AMSTERDAM HOSP,DEPT ONCOL 1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
European journal of cancer
fascicolo: 6, volume: 31A, anno: 1995,
pagine: 974 - 976
SICI:
0959-8049(1995)31A:6<974:MOTAOC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; N-(PHOSPHONACETYL)-L-ASPARTIC ACID; PHASE-II; 5-FLUOROURACIL; INFUSION; PALA; HEAD; NECK; FLUOROURACIL; THERAPY;
Keywords:
PALA; CISPLATIN; FDURD; COLON 26;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.A.M. Vanlaar et al., "MODULATION OF THE ANTITUMOR-ACTIVITY OF CISPLATIN ALONE AND IN COMBINATION WITH 5-FLUORO-2'-DEOXYURIDINE BY N-PHOSPHONACETYL-L-ASPARTATE INMURINE COLON-CARCINOMA NO-26", European journal of cancer, 31A(6), 1995, pp. 974-976

Abstract

Modulation of the therapeutic efficacy of cisplatin (CDDP) and 5-fluoro-2'-deoxyuridine (FdUrd) alone and in combination with N-phosphonacetyl-L-aspartate (PALA) was evaluated in mice bearing colon carcinoma (C-26) using a weekly intravenous (i.v.) push schedule for 3 weeks. A non-toxic dose of PALA (100 mg/kg) was administered i.v. 24 h prior to the i.v. administration of CDDP +/- FdUrd. The maximum tolerated doses((MTD) of CDDP and FdUrd when used as a single agent were 9 and 400 mg/kg, respectively. In combination, however, the MTD of CDDP and FdUrdwere 2.5 and 300 mg/kg, respectively. PALA did not significantly affect the MTD. PALA improved the antitumour activity of CDDP or FdUrd when used alone; however, the highest tumour response, 66% complete tumour regression, was achieved with a PALA modulation of CDDP and FdUrd incombination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:16:56