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Titolo:
CEREBELLAR BLOOD-FLOW IN SCHIZOPHRENIC-PATIENTS AND NORMAL CONTROL SUBJECTS
Autore:
STEINBERG JL; DEVOUS MD; MOELLER FG; PAULMAN RG; RAESE JD; GREGORY RR;
Indirizzi:
DEPT VET AFFAIRS MED CTR,PSYCHIAT SERV 116A,4500 S LANCASTER RD DALLAS TX 75216 UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT DALLAS TX 75235 UNIV TEXAS,SW MED CTR,CTR NUCL MED,DEPT RADIOL DALLAS TX 75235
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 61, anno: 1995,
pagine: 15 - 31
SICI:
0925-4927(1995)61:1<15:CBISAN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; INERT-GAS CONCENTRATIONS; FRONTAL-LOBE LESIONS; COMPUTED-TOMOGRAPHY; PSYCHIATRIC-DISORDERS; OXIDATIVE-METABOLISM; MENTAL SKILLS; ATROPHY; PATHOLOGY;
Keywords:
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SCHIZOPHRENIA DISORDER; WISCONSIN CARD SORTING TEST; NUMBER MATCHING TEST; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Steinberg et al., "CEREBELLAR BLOOD-FLOW IN SCHIZOPHRENIC-PATIENTS AND NORMAL CONTROL SUBJECTS", PSYCHIATRY RESEARCH-NEUROIMAGING, 61(1), 1995, pp. 15-31

Abstract

We used Xe-133 dynamic single-photon emission computed tomography (DSPECT) to measure the resting cerebellar blood flow in 17 neuroleptic-free schizophrenic and schizophreniform patients and 13 normal control subjects. A subset of these subjects (11 patients and 7 control subjects) additionally underwent activation studies during the Wisconsin Card Sorting (WCS) and Number Matching (NM) tests. Baseline relative cerebellar blood flow was significantly lower in older patients than in age-matched control subjects. For absolute cerebellar flow, there was a significant difference between patients and control subjects in the overall activation response (patients: NM 13.4% increase, WCS 15.7% increase; control subjects: NM 3.1% decrease, WCS 0.0% change). This difference was more pronounced in older subjects. Cerebral blood flow significantly increased during NM (patients: 21.3% increase, control subjects: 6.5% increase) and WCS (patients: 16.5% increase, control subjects: 9.7% increase). The difference in the magnitude of cerebral NM activation between schizophrenic patients and control subjects, although not statistically significant, may call into question the appropriateness of using NM asa control task in schizophrenic patients. Finally, we found no differences between the effects of WCS and NM on cerebellar or cerebral blood flow. Because of the small number of subjects in eachgroup, the results of this study should be interpreted cautiously.

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Documento generato il 18/01/20 alle ore 07:35:31