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Titolo:
ONTOGENY OF THE EFFECT OF ANTIPSYCHOTIC DRUG-TREATMENT ON NEUROTENSINCONCENTRATIONS IN THE RAT-BRAIN
Autore:
KINKEAD B; OWENS MJ; NEMEROFF CB;
Indirizzi:
EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,NEUROPSYCHOPHARMACOL LAB,POB DRAWER AF ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,NEUROPSYCHOPHARMACOL LABATLANTA GA 30322
Titolo Testata:
Synapse
fascicolo: 3, volume: 20, anno: 1995,
pagine: 244 - 248
SICI:
0887-4476(1995)20:3<244:OOTEOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; DOPAMINERGIC-NEURONS; POSTNATAL ONTOGENY; SUBSTANTIA-NIGRA; BINDING-SITES; HALOPERIDOL; LOCALIZATION; NEUROLEPTICS; APOMORPHINE; NEOSTRIATUM;
Keywords:
TYPICAL ANTIPSYCHOTIC; HALOPERIDOL; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
B. Kinkead et al., "ONTOGENY OF THE EFFECT OF ANTIPSYCHOTIC DRUG-TREATMENT ON NEUROTENSINCONCENTRATIONS IN THE RAT-BRAIN", Synapse, 20(3), 1995, pp. 244-248

Abstract

It has been well documented that treatment with haloperidol and othertypical antipsychotic drugs increase neurotensin (NT) concentrations in the nucleus accumbens and caudate nucleus in adult rats. The NT neuronal system has been found to undergo distinct age-related changes inthe rat brain, and therefore, it is of interest to examine the ontogeny of the effects of antipsychotic drug treatment on NT concentrations. In order to determine when, or if, antipsychotic drug treatment has an effect on NT-containing neurons in the developing rat, rat pups received a single dose of haloperidol (2.0 mg/kg, s.c.) or vehicle at 9, 14, or 20 days after birth. Regional brain NT concentrations were thenmeasured using a sensitive and specific radioimmunoassay. Treatment with haloperidol had no effect on NT concentrations in any brain regionin 10-day-old rat pups. At 15 days of age, haloperidol significantly increased NT concentrations in the caudate nucleus (120% of control, P< 0.05). At 21 days of age, haloperidol increased NT concentrations in the caudate nucleus (193% of control, P < 0.001) and nucleus accumbens (126% of control, P < 0.005) similar to that seen in adult animals. There were no statistically significant gender-related differences found in any age or treatment group studied. These findings indicate that there is a specific time point during postnatal development when ratbrain NT systems become responsive to antipsychotic drug administration. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:13:17