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Titolo:
IMMUNOCYTOCHEMICAL LOCALIZATION OF PLASMINOGEN ACTIVATORS IN CARCINOMAS OF THE CERVIX AND VULVA
Autore:
PAROLINI S; ROAS D; FLAGIELLO D; BONARDI F; RAMPINELLI F; BIANCHI UA; TOSATTI MPM;
Indirizzi:
UNIV BRESCIA,INST HISTOL & CYTOL,DEPT BIOMED & BIOTECHNOL SCI,19 VIA VALSABBINA I-25123 BRESCIA ITALY UNIV BRESCIA,INST HISTOL & CYTOL,DEPT BIOMED & BIOTECHNOL SCI I-25123BRESCIA ITALY UNIV BRESCIA,DEPT OBSTET & GYNAECOL BRESCIA ITALY
Titolo Testata:
International journal on tissue reactions
fascicolo: 5-6, volume: 16, anno: 1994,
pagine: 251 - 258
SICI:
0250-0868(1994)16:5-6<251:ILOPAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
UROKINASE-TYPE; CLINICAL-SIGNIFICANCE; EXTRACELLULAR-MATRIX; INHIBITOR PAI-2; BREAST-CANCER; CELL-LINES; TISSUE; TUMORS; RECEPTOR; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S. Parolini et al., "IMMUNOCYTOCHEMICAL LOCALIZATION OF PLASMINOGEN ACTIVATORS IN CARCINOMAS OF THE CERVIX AND VULVA", International journal on tissue reactions, 16(5-6), 1994, pp. 251-258

Abstract

The presence of plasminogen activators (PA) in a variety of solid tumours appears to correlate, in a number of instances, with enhanced invasive and/or metastatic ability. Urokinase and tissue-type plasminogenactivators (u-PA and t-PA) in normal and neoplastic tissues of cervixand of vulva were immunohistochemically identified by means of polycyclonal antibodies. In addition, frozen sections were analysed for u-PAand t-PA activity by in-situ zymography technique. Data collected in our study showed that in invasive cancer u-PA increased more in malignant cells as compared to normal cells in both the inactive and active enzymatic forms. The t-PA distribution pattern was related to angiogenesis while it did not relate to the degree of tumour differentiation. A synergic interaction between proteolytic tumoral activity and proteolytic inflammatory action could be hypothesized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:19:14