Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF DOPAMINE ON ISOLATED FAILING RAT-HEART
Autore:
PATERNA S; DIPASQUALE P; ANTONA A; DAMICO C; LISTRO G; BUCCA V; PALAZZOADRIANO M; ARROSTUTO A; CANNAVO MG; SCALZO S;
Indirizzi:
GF INGRASSIA HOSP,DEPT CARDIOL,3 VIA VAL PLATANI I-90144 PALERMO ITALY GF INGRASSIA HOSP,DEPT CARDIOL I-90144 PALERMO ITALY UNIV PALERMO,DEPT INTERNAL MED PALERMO ITALY UNIV PALERMO,INST PHARMACOL PALERMO ITALY
Titolo Testata:
International journal on tissue reactions
fascicolo: 5-6, volume: 16, anno: 1994,
pagine: 243 - 250
SICI:
0250-0868(1994)16:5-6<243:EODOIF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS; EPININE; RENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Paterna et al., "EFFECTS OF DOPAMINE ON ISOLATED FAILING RAT-HEART", International journal on tissue reactions, 16(5-6), 1994, pp. 243-250

Abstract

Dopamine has been used for many years to treat patients with severe heart failure. it is not clear whether improvements of cardiac functionmay be due to a direct action on heart. This study was aimed to investigate the direct action of dopamine on failing heart. We chose male Wistar rats which had undergone uninephrectomy under ether anaesthesia to induce hypertension to result in heart failure. After 5 weeks the hearts were excised and perfused according to Langerdoff's technique. Heart rate, systolic and diastolic ventricular pressures, the derivative of the intraventricular pressure lime ratio, and coronary flow were measured at baseline, at 2 and 5 min and then every 5 min during a 30-min period. Rat hearts were divided into 4 groups of 5 hearts: group 1, perfused without drug; group 2, perfused with dopamine at 4 mu g/kg/min; group 3, perfused with dopamine at 8 mu g/kg/min; group 4, perfused with dopamine al 8 mu g/kg/min and with 100 nM I. C.I. 118.551 (beta 2-ant: beta-2 receptors antagonist) at the same time. Our results show that dopamine induced a negative inotropic effect and a reduction oi coronary flow. Moreover, there was a significant chronotropic actioneven when dopamine was administered at high concentrations. So we found no positive dopamine effect on isolated failured hearts of rat. This might be explained by both alpha-1-induced vasoconstriction and the stimulation of alpha-1B receptors. We conclude that the favourable effects or dopamine in heart failure could be due to DA1 vasodilation rather than to a direct inotropic action on the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:53:07