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Titolo:
PLATELET MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION IN PARKINSONS-DISEASE
Autore:
BLAKE CI; SPITZ E; LEEHEY M; HOFFER BJ; BOYSON SJ;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT,BOX C268-71,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT NEUROL DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL DENVER CO 80262
Titolo Testata:
Movement disorders
fascicolo: 1, volume: 12, anno: 1997,
pagine: 3 - 8
SICI:
0885-3185(1997)12:1<3:PMRFIP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX-I DEFICIENCY; SKELETAL-MUSCLE; UBIQUINONE OXIDOREDUCTASE; ENVIRONMENTAL TOXINS; ENZYME-ACTIVITIES; OXIDANT STRESS; BRAIN; ABNORMALITIES; LYMPHOCYTES; DYSFUNCTION;
Keywords:
PARKINSONS DISEASE; COMPLEX I; NADH DEHYDROGENASE; UBIQUINONE; COMPLEX III; UBIQUINOL CYTOCHROME C REDUCTASE; COMPLEX IV; CYTOCHROME C OXIDASE; CITRATE SYNTHASE; BLOOD PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.I. Blake et al., "PLATELET MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION IN PARKINSONS-DISEASE", Movement disorders, 12(1), 1997, pp. 3-8

Abstract

Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support theoxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age-matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS-corrected, activities were significantly positively correlated withCi in combined and individual group data, with the exception of CIII CS-corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age inCON, but varied randomly in PD. In PD, CIII specific activity was 1.4-fold higher in those with a history of environmental risk factors forPD and CIV specific activity was lower in those with a positive family history of PD [8.34 +/- 0.74 (n = 4) vs. 12.4 +/- 1.1 (SEM) min(-1) mg(-1); p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:53:28