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Titolo:
EFFECTS OF KAPPA-OPIOID RECEPTOR AGONISTS ON STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN RAT-KIDNEY
Autore:
MOSADDEGHI M; KAPUSTA DR; MINOR LD; DUAN N; PAUL D;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL,1901 PERDIDO ST NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,LOUISIANA ALCHOL & DRUG ABUSE CTR NEW ORLEANS LA 70112
Titolo Testata:
European journal of pharmacology. Molecular pharmacology section
fascicolo: 3, volume: 289, anno: 1995,
pagine: 411 - 417
SICI:
0922-4106(1995)289:3<411:EOKRAO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; NALOXONE BENZOYLHYDRAZONE; CHOLINERGIC STIMULATION; INOSITOL TRISPHOSPHATE; SIGNAL TRANSDUCTION; DIURETIC ACTIVITY; CORTICAL SLICES; 2ND MESSENGER; RENAL NERVES; BRAIN;
Keywords:
PHOSPHOLIPID METABOLISM; U50,488; ETHYLKETOCYCLAZOCINE; NOREPINEPHRINE; CARBACHOL; RENAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Mosaddeghi et al., "EFFECTS OF KAPPA-OPIOID RECEPTOR AGONISTS ON STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN RAT-KIDNEY", European journal of pharmacology. Molecular pharmacology section, 289(3), 1995, pp. 411-417

Abstract

To determine the effects of kappa-opioid receptor agonists on phosphoinositide metabolism in rat renal cortex, tissue slices labelled with [H-3]inositol were stimulated with norepinephrine or carbachol alone or in combination with the kappa-opioid receptor agonists, ethylketocyclazocine, -N-[2-(pyrrolindinyl)-cyclohexyl)-benzeneacetamide (U50,488)and nalorphine. Both norepinephrine and carbachol stimulated phosphoinositide hydrolysis (measured in a LiCl buffer) concentration- and time-dependently. The EC(50) and maximal stimulation of phosphoinositide hydrolysis for norepinephrine and carbachol were approximately 3 mu M and 0.15 dpm released/dpm incorporated, respectively. Concentrations up to 1 mM of ethylketocyclazocine, U50,488 or nalorphine alone did notaffect phosphoinositide hydrolysis. However, ethylketocyclazocine andU50,488 decreased 10 mu M norepinephrine-stimulated phosphoinositide hydrolysis concentration-dependently, each with an approximate IC50 of30 mu M. In contrast, nalorphine had no effect on norepinephrine-stimulated phosphoinositide hydrolysis. In addition, concentrations of up to 1 mM ethylketocyclazocine or U50,488 did not alter carbachol-stimulated phosphoinositide hydrolysis. The inhibitory effect of U50,488 andethylketocyclazocine on norepinephrine-stimulated phosphoinositide hydrolysis was blocked by the selective kappa-opioid receptor antagonist, nor-binaltorphimine. These results indicate that kappa(1)-opioid receptor stimulation may affect phosphoinositide metabolism in rat renal cortex by modulating the subcellular effects of renal alpha(1)-adrenoceptor activation.

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Documento generato il 14/07/20 alle ore 18:27:48