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Titolo:
OVARIAN TERATOMAS IN MICE LACKING THE PROTOONCOGENE C-MOS
Autore:
FURUTA Y; SHIGETANI Y; TAKEDA N; IWASAKI K; IKAWA Y; AIZAWA S;
Indirizzi:
KUMAMOTO UNIV,SCH MED,IMEG,DEPT MORPHOGENESIS,2-2-1 HONJO KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,IMEG,DEPT MORPHOGENESIS KUMAMOTO 860 JAPAN RIKEN,INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR TSUKUBA IBARAKI 305 JAPAN TOKYO MED & DENT UNIV,SCH MED,DEPT BIOCHEM,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Japanese journal of cancer research
fascicolo: 6, volume: 86, anno: 1995,
pagine: 540 - 545
SICI:
0910-5050(1995)86:6<540:OTIMLT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTO-ONCOGENE PRODUCT; XENOPUS OOCYTES; SARCOMA-VIRUS; EGGS;
Keywords:
OVARIAN TERATOMA; C-MOS; PARTHENOGENESIS; MUTANT MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y. Furuta et al., "OVARIAN TERATOMAS IN MICE LACKING THE PROTOONCOGENE C-MOS", Japanese journal of cancer research, 86(6), 1995, pp. 540-545

Abstract

Parthenogenesis has been suggested to be tightly coupled with development of ovarian teratomas. Indeed, ovarian tumors developed in c-mos-deficient female mice, which are characterized by the parthenogenetic activation of oocytes. The tumors appeared at a frequency of 30% between 4 and 8 months of age, and did not develop in younger or older mice. Most of the tumors were benign and consisted of multi-focal cysts most notably with mature ectodermal components, but also with mesodermal and endodermal components. One among 17 tumors observed consisted of extra-embryonic tissues alone, and two bore malignant components with metastasis to peritoneal organs. The results strongly suggest the involvement of c-mos mutations in human germ cell tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 02:54:26