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Titolo:
ANALYSIS OF MESOCARB ANALOGS IN URINE AND PLASMA OF RATS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY
Autore:
PYO H; PARK SJ; PARK J; YOO JK; YOON B;
Indirizzi:
KOREA INST SCI & TECHNOL,DOPING CONTROL CTR,POB 131 CHEONGRYANG SEOULSOUTH KOREA YON SEI UNIV,DEPT CHEM SEOUL SOUTH KOREA
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 687, anno: 1996,
pagine: 261 - 269
Fonte:
ISI
Lingua:
ENG
Keywords:
DOPING AGENTS; MESOCARB; 2-HYDROXYMESOCARB; 4-METHYL-2-HYDROXYMESOCARB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
H. Pyo et al., "ANALYSIS OF MESOCARB ANALOGS IN URINE AND PLASMA OF RATS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY", Journal of chromatography B. Biomedical applications, 687(1), 1996, pp. 261-269

Abstract

The pharmacokinetics and metabolism of synthetic 2-hydroxymesocarb and 4-methyl-2-hydroxymesocarb analyzed by HPLC-DAD and thermospray LC-MS were studied in rats. Multistep liquid-liquid extraction (LLE) was used with diethyl ether at pH 7.0. The major metabolites of 2-hydroxymesocarb in both urine and plasma of the rat were the p-hydroxylated derivative of the phenylcarbamoyl group of the parent drug. The metabolites of 4-methyl-2-hydroxymesocarb in urine of rats may be the oxidized forms at the phenylcarbamoyl group of the parent drug. Absorption (k(a)) and elimination (k(e)) rate constants in plasma of 2-hydroxy-mesocarb were 0.0300 and 0.00485 min(-1), respectively; those of 4-methyl-2-hydroxymesocarb were 0.0546 and 0.00797 min(-1), respectively. The half-lives (t(1/2)) of 2-hydroxymesocarb and 4-methyl-2-hydroxymesocarb in plasma were 144 and 86 min, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 09:48:34