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Titolo:
CEREBROSPINAL-FLUID MONOAMINE METABOLITES IN CHILDHOOD-ONSET SCHIZOPHRENIA
Autore:
JACOBSEN LK; FRAZIER JA; MALHOTRA AK; KAROUM F; MCKENNA K; GORDON CT; HAMBURGER SD; LENANE MC; PICKAR D; POTTER WZ; RAPOPORT JL;
Indirizzi:
NIMH,CHILD PSYCHIAT BRANCH,BLDG 10,RM 6N240,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIMH,ANALYT BIOCHEM LAB WASHINGTON DC 00000 NIMH,EXPT THERAPEUT BRANCH BETHESDA MD 20892
Titolo Testata:
The American journal of psychiatry
fascicolo: 1, volume: 154, anno: 1997,
pagine: 69 - 74
SICI:
0002-953X(1997)154:1<69:CMMICS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMOVANILLIC-ACID; NEUROLEPTIC TREATMENT; PSYCHIATRIC-PATIENTS; CLOZAPINE; PROLACTIN; SEROTONIN; CHLORPROMAZINE; NOREPINEPHRINE; IMMUNOGLOBULIN; PATTERNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
L.K. Jacobsen et al., "CEREBROSPINAL-FLUID MONOAMINE METABOLITES IN CHILDHOOD-ONSET SCHIZOPHRENIA", The American journal of psychiatry, 154(1), 1997, pp. 69-74

Abstract

Objective: Pediatric studies of cerebrospinal fluid (CSF) monoamine metabolites in childhood-onset schizophrenia may help to elucidate bothpathophysiology and treatment response in early-onset psychosis. Method: CSF homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) and serum prolactin were measured during drug-free and antipsychotic medication conditions in 18 patients (mean age=14.2 years, SD=1.7) who had onset of schizophrenia by age 12 (mean age at onset=9.9 years, SD=1.8). Relationships betweenchanges in CSF monoamines and serum prolactin and clinical outcome were examined, and the degree of change in CSF monoamines in response toclozapine treatment was compared with that for 16 patients with later-onset schizophrenia. Results: Despite patients' significant clinical improvement with treatment, CSF monoamine concentrations and ratios ofHVA/5-HIAA and HVA/MHPG did not significantly change with 6 weeks of either haloperidol or clozapine treatment. Serum prolactin levels increased during haloperidol treatment. Clozapine had similar effects on CSF monoamines inpatients with childhood- and later-onset schizophrenia. Conclusions: While these data are compatible with continuity betweenchildhood- and later-onset schizophrenia, they also highlight the complexity of the biochemical events mediating clinical changes in schizophrenia.

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Documento generato il 10/07/20 alle ore 18:46:40