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Titolo:
EFFECTS OF METHYLPHENIDATE ON REGIONAL BRAIN GLUCOSE-METABOLISM IN HUMANS - RELATIONSHIP TO DOPAMINE D-2 RECEPTORS
Autore:
VOLKOW ND; WANG GJ; FOWLER JS; LOGAN J; ANGRIST B; HITZEMANN R; LIEBERMAN J; PAPPAS N;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED,BLDG 490 UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 NYU,DEPT PSYCHIAT NEW YORK NY 10016 HILLSIDE HOSP GLEN OAKS NY 11004
Titolo Testata:
The American journal of psychiatry
fascicolo: 1, volume: 154, anno: 1997,
pagine: 50 - 55
SICI:
0002-953X(1997)154:1<50:EOMORB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; THREO-METHYLPHENIDATE; ENERGY-METABOLISM; C-11 RACLOPRIDE; RAT-BRAIN; SCHIZOPHRENIA; COCAINE; BINDING; MODEL; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "EFFECTS OF METHYLPHENIDATE ON REGIONAL BRAIN GLUCOSE-METABOLISM IN HUMANS - RELATIONSHIP TO DOPAMINE D-2 RECEPTORS", The American journal of psychiatry, 154(1), 1997, pp. 50-55

Abstract

Objective: The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assessthe pattern of metabolic responses associated with enhanced dopamine activity. Method: They used positron emission tomography with 2-deoxy-2[18F]fluoro-D-glucose to evaluate the effects of two sequential dosesof methylphenidate on brain metabolism in 15 healthy subjects. Dopamine D-2 receptor availability was measured with [11C]raclopride to evaluate its relation to methylphenidate-induced metabolic changes. Results: Methylphenidate increased brain metabolism in six subjects, decreased it in two, and did not change it in seven; however, it consistentlyincreased cerebellar metabolism. Methylphenidate significantly increased ''relative'' (region relative to the whole brain) metabolism in the cerebellum and decreased it in the basal ganglia. Regional metabolicchanges in the cerebellum and the frontal and temporal cortices were significantly correlated with D-2 availability. Frontal and temporal metabolism were increased in subjects with high D-2 receptors and decreased in subjects with low D-2 receptors. Conclusions: Methylphenidate induced variable changes in brain metabolism, but it consistently increased cerebellar metabolism. It also induced a significant reduction in relative metabolism in the basal ganglia. The significant association between metabolic changes in the frontal and temporal cortices and in the cerebellum and D-2 receptors suggests that methylphenidate's metabolic effects in these brain regions are due in part to dopamine changes and that differences in D-2 receptors may be one of the mechanismsaccounting for the variability in response to methylphenidate.

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Documento generato il 02/04/20 alle ore 00:01:21