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Titolo:
DEMONSTRATION OF A SPECIFIC PROFILE OF PA THOLOGICAL TAU-PROTEINS IN FRONTOTEMPORAL DEMENTIA CASES
Autore:
VERMERSCH P; BORDET R; LEDOZE F; RUCHOUX MM; CHAPON F; THOMAS P; DESTEE A; LECHEVALLIER B; DELACOURTE A;
Indirizzi:
INSERM,U422,PL VERDUN F-59045 LILLE FRANCE INSERM,U422 F-59045 LILLE FRANCE CHU LILLE,HOP B,SERV CLIN NEUROL F-59037 LILLE FRANCE CHU COTE NACRE,SERV NEUROL F-14000 CAEN FRANCE CHU LILLE,HOP B,NEUROPATHOL LAB F-59037 LILLE FRANCE CHU COTE NACRE,NEUROPATHOL LAB F-14000 CAEN FRANCE CHU LILLE,SERV PSYCHIAT GEN F-59037 LILLE FRANCE
Titolo Testata:
Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie
fascicolo: 4, volume: 318, anno: 1995,
pagine: 439 - 445
SICI:
0764-4469(1995)318:4<439:DOASPO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
FRE
Soggetto:
FRONTAL-LOBE DEGENERATION; NON-ALZHEIMER TYPE; NEUROFIBRILLARY DEGENERATION; DISEASE; NEUROPATHOLOGY;
Keywords:
FRONTOTEMPORAL DEMENTIA; ALZHEIMERS DISEASE; TAU PROTEINS; NEURODEGENERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P. Vermersch et al., "DEMONSTRATION OF A SPECIFIC PROFILE OF PA THOLOGICAL TAU-PROTEINS IN FRONTOTEMPORAL DEMENTIA CASES", Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie, 318(4), 1995, pp. 439-445

Abstract

We compared samples of different brain areas from patients with Alzheimer's disease (AD), progressive supranuclear palsy (PSP), controls subjects and from 4 patients who met the clinical and pathological criteria for frontotemporal dementia (FTD), wing a Western blot analysis. We used polyclonal antibodies directed against Tau proteins and the monoclonal antibody AD2 for the immunodetection of the pathological Tau proteins which are the basic components of neurofibrillary degeneration. lit the PSP and AD cases, we respectively detected the abnormal Tau proteins Gk and 69 and the Tau proteins 55, 64 and 69, systematically associated with bands and smears, corresponding to catabolic products or agregates of these abnormal Tau proteins. In FTD cases, the abnormal Tau proteins 55, 64 and 69 were also detected in the frontal and temporal poles from the autopsied case and in the cortical biopsies. However, the profiles were different because smears and proteolytics products of Tau proteins were absent. There was no detection of abnormal Tau proteins in control brain homogenates and in biopsies from patients with other neurodegenerative disorders such as spongiform encephalopathies or primitive gliosis. These results demonstrate that pathologicalTau proteins are produced during FTD degenerating process, despite the absence of neurofibrillary lesions.

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Documento generato il 28/11/20 alle ore 03:38:08