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Titolo:
FIBRILLIN-1 AND FIBRILLIN-2 SHOW TEMPORAL AND TISSUE-SPECIFIC REGULATION OF EXPRESSION IN DEVELOPING ELASTIC TISSUES
Autore:
MARIENCHECK MC; DAVIS EC; ZHANG H; RAMIREZ F; ROSENBLOOM J; GIBSON MA; PARKS WC; MECHAM RP;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT CELL BIOL & PHYSIOL,BOX 8228,660 S EUCLID ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT CELL BIOL & PHYSIOL ST LOUIS MO 63110 MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL NEW YORK NY 00000 UNIV PENN,SCH DENT MED PHILADELPHIA PA 19104 UNIV ADELAIDE,DEPT PATHOL ADELAIDE SA AUSTRALIA UNIV WASHINGTON,JEWISH HOSP,SCH MED,DEPT MED,DIV DERMATOL ST LOUIS MO00000 UNIV WASHINGTON,JEWISH HOSP,SCH MED,DEPT MED,DIV RESP & CRIT CARE ST LOUIS MO 00000
Titolo Testata:
Connective tissue research
fascicolo: 2, volume: 31, anno: 1995,
pagine: 87 - 97
SICI:
0300-8207(1995)31:2<87:FAFSTA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROFIBRIL-ASSOCIATED GLYCOPROTEIN; MARFAN-SYNDROME; COMPONENT; PROTEIN; GENE; MAGP; ORGANIZATION; SEQUENCE; LINKAGE; AORTA;
Keywords:
FIBRILLIN; MAGP; ELASTIN; MICROFIBRILS; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Mariencheck et al., "FIBRILLIN-1 AND FIBRILLIN-2 SHOW TEMPORAL AND TISSUE-SPECIFIC REGULATION OF EXPRESSION IN DEVELOPING ELASTIC TISSUES", Connective tissue research, 31(2), 1995, pp. 87-97

Abstract

The recent characterization of multiple fibrillin genes raises the question of whether each of the fibrillin proteins is a component of elastic fiber microfibrils and whether their expression during development of elastic tissues is consistent with a function associated with elastogenesis. To address these possibilities, the expression of fibrillin-1 and fibrillin-2 was compared with expression of MAGP and tropoelastin in two elastogenic tissues that undergo different developmental programs. For both fibrillins, the greatest increase in expression occurred during the last half of fetal development when elastin production is highest. In fetal bovine nuchal ligament, mRNA levels for fibrillin-1 and fibrillin-2 increased approximately threefold during this period, whereas tropoelastin increased 20-fold. Although the relative increase in expression of both fibrillins was equivalent, the basal level of fibrillin-1 expression was greater than fibrillin-2. In developing bovine aorta, fibrillin mRNA levels again paralleled tropoelastin expression although, compared to ligament, elastin synthesis began at an earlier fetal age in this tissue. Furthermore, the relative increase in aortic fibrillin-2 expression was greater than that for fibrillin-l and the ratio of fibrillin-2 to fibrillin-l was higher than in the ligament. In contrast to the fibrillins, MAGP expression in nuchal ligamentand aorta remained at a constant high level throughout the fetal period. Indirect immunofluorescent staining and immunoelectron microscopy localized both fibrillins as well as MAGP to elastic fiber microfibrils in these developing tissues. The coordinate upregulation of fibrillin-l and fibrillin-2 expression with the onset of tropoelastin production is consistent with a role in elastic fiber assembly. Our findings also suggest temporal and tissue-specific regulation for the fibrillinsduring development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:04:05