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Titolo:
ANIRACETAM REVERSES MEMORY IMPAIRMENT IN RATS
Autore:
MARTIN JR; MOREAU JL; JENCK F;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN RES,PRPN,BLDG 72-150,GRENZACHERSTR 124 CH-4002 BASEL SWITZERLAND
Titolo Testata:
Pharmacological research
fascicolo: 2, volume: 31, anno: 1995,
pagine: 133 - 136
SICI:
1043-6618(1995)31:2<133:ARMIIR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIATION; RECEPTORS; CULTURES;
Keywords:
ANIRACETAM; PASSIVE AVOIDANCE; NOOTROPIC; SCOPOLAMINE-INDUCED AMNESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Martin et al., "ANIRACETAM REVERSES MEMORY IMPAIRMENT IN RATS", Pharmacological research, 31(2), 1995, pp. 133-136

Abstract

The pyrrolidinone derivative aniracetam given orally immediately after acquisition of an inhibitory avoidance response reproducibly ameliorated scopolamine-induced amnesia in female rats in an extensive seriesof test sessions conducted over a 1-year period. In a dose-response experiment it was demonstrated that 50 mg kg(-1) was the lowest oral dose of aniracetam to significantly ameliorate scopolamine-induced amnesia. Combined results from these numerous test sessions demonstrated that 50 mg kg(-1) aniracetam administered to scopolamine-treated rats resulted in 53% of the animals exhibiting correct passive avoidance responding in the retention evaluation versus 9% of the scopolamine-treated rats given vehicle (in comparison, 64% of the rats injected with vehicle rather than scopolamine in this experimental situation exhibited correct responding in the retention test). There was minimal variationin this pattern of results over the successive 1-month blocks constituting the complete experimental period. Thus, the nootropic compound aniracetam replicably exhibited memory enhancing effects in this animalmodel of reduced cholinergic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:49:58