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Titolo:
PHARMACOTOXICOLOGICAL ASPECTS OF LEVOSULPIRIDE
Autore:
ROSSI F; FORGIONE A;
Indirizzi:
UNIV NAPLES 2,FAC MED & SURG,INST PHARMACOL & TOXICOL,VIA BROGGIA 3 I-80128 NAPLES ITALY
Titolo Testata:
Pharmacological research
fascicolo: 2, volume: 31, anno: 1995,
pagine: 81 - 94
SICI:
1043-6618(1995)31:2<81:PAOL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED BENZAMIDE DRUGS; DOPAMINE-RECEPTORS; SCHIZOPHRENIC-PATIENTS; RAT-BRAIN; SULPIRIDE; METABOLISM; DA1; PHARMACOLOGY; IMPROVEMENT; FENOLDOPAM;
Keywords:
SULPIRIDE; LEVOSULPIRIDE; DOPAMINERGIC NEURONAL PATHWAYS; PHARMACOTOXICOLOGIC SURVEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
F. Rossi e A. Forgione, "PHARMACOTOXICOLOGICAL ASPECTS OF LEVOSULPIRIDE", Pharmacological research, 31(2), 1995, pp. 81-94

Abstract

Levosulpiride is the levorotatory enantiomer of sulpiride, a substituted benzamide indicated as an antipsychotic, antidepressant, antiemetic and antidyspeptic drug, as well as for the treatment of somatoform disorders. In vivo sulpiride displays a number of neuroleptic properties which it shares with all typical neuroleptic drugs; however, it has also a number of divergent characteristics that set it apart as the principal compound of the so-called 'atypical neuroleptic agents'. The main mechanism of action of levosulpiride consists of blocking the D-2 dopaminergic receptors, preferentially located on the presynaptic membranes in the dopaminergic pathways of the brain; this means that sulpiride is a selective autoreceptor blocker. The results of series of experimental trials conducted to evaluate the toxicologic characteristicsof levosulpiride are presented. Both the acute, subacute, chronic andlocal toxicity trials, and the studies on reproduction toxicity, mutagenic potential and oncogenic/carcinogenic potential, demonstrate thatlevosulpiride is well tolerated by the animals tested (rats, mice, rabbits and dogs) at doses higher than those effective in human therapy. Moreover, the findings from the experimental studies on levosulpiridelead to exclude the toxicity from accumulation, tolerance, dependenceor withdrawal syndrome. In conclusion, according to the evaluated preclinical studies, levosulpiride shows pharmacotoxicologic properties which make it suitable for the management of diseases for which the drug is indicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:23:34