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Titolo:
GROWTH-HORMONE TREATMENT IN PREPUBERTAL S HORT CHILDREN WITH NON CLASSICAL GH DEFICIENCY - FOLLOW-UP AFTER 42 MONTHS
Autore:
SAGGESE G; CESARETTI G; ROSSI A; FRANCHI G;
Indirizzi:
UNIV PISA,IST CLIN PEDIAT,CATTEDRA PEDIAT PREVENT & SOCIALE,VIA ROMA 67 I-56125 PISA ITALY
Titolo Testata:
Rivista italiana di pediatria
fascicolo: 6, volume: 20, anno: 1994,
pagine: 625 - 635
SICI:
0392-5161(1994)20:6<625:GTIPSH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ITA
Keywords:
NONCLASSICAL GN DEFICIENCY; GH TREATMENT; HEIGHT VELOCITY; STATURAL PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
G. Saggese et al., "GROWTH-HORMONE TREATMENT IN PREPUBERTAL S HORT CHILDREN WITH NON CLASSICAL GH DEFICIENCY - FOLLOW-UP AFTER 42 MONTHS", Rivista italiana di pediatria, 20(6), 1994, pp. 625-635

Abstract

In this paper the authors examined the results of growth hormone (GH)treatment in a group of 46 shout children (29 M, 17 F) with reduced height velocity (HV) suffering from non classical GH deficiency (normalGH response to provocative tests, but diminished 24-hour spontaneous secretion). GH treatment, already in progress, has been performed for a period of 12-42 months (mean: 34.69 months) at the dose of 12 IU/sqm/week. During GH therapy there was a significant increase in comparison to pre-treatment values in height SD scores (SDs) (-1.52+/-0.38 (m+/-SD) vs -2.57+/-0.36, p < 0.001) and ill HVSDs (+1.96+/-0.85 vs -2.60+/-0.62, p < 0.001). Considering the individual cases, 36 (78.3%) subjects showed a gain in HV higher than +4 SDs. HV progressively decreasedduring the semesters (waning effect). Actual final predicted height resulted higher than that before the beginning of treatment (164.2+/-4.7 vs 157.5+/-4.0 cm, p < 0.001), whereas the Delta height age/Delta bone age ratio, resulted 1.18+/-0.11, suggesting a favourable effect of the treatment on statural prognosis. A negative correlation between gain in HV and pre-treatment HV (r = - 0.38, p < 0.01) occurred, whereasthere was no correlation between growth response to therapy and the other hormonal or auxological parameters. In conclusion, GH treatment of subjects with non classical GH deficiency was effective in increasing HV and statural prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:46:47